| HRM | Pyro | Cobas | IHC | NGS | Sanger |
---|---|---|---|---|---|---|
CE mark | No | No | Yes | No | No | No |
Limit of detection [%] | 6.6 | 5 | 7 | 5 | 2 | 6.6 |
Detection of rare mutations | Yes | Yes- downstream of codon 600 | No- 4 different mutations | No- p.V600E | Yes | Yes |
Specificity [%] | 100 | 90 | 98.3 | 98 | 100 | 100 |
Turnaround time | 1Â day | 2Â days | 1Â day | 1Â day | 3 - 5 days | 2 - 3 days |
Costs | Low | High | Medium | Low | Very high | Medium |