Table 3 Survival rates according to genomic regions
From: Impact of chromosomal instability on colorectal cancer progression and outcome
Genomic regions | S2S3PT (n=72) | RFS | OS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
No. of relapse | HR | 95% CI | 3-year RFS rate (%) | No. of death | HR | 95% CI | 5-year OS rate (%) | |||
chr16p13.3 | Normal | 49 (68.1%) | 13 | 1 | 72.8 | 11 | 1 | 71.8 | ||
chr16:0-2,410,722 | Gain | 16 (22.2%) | 5 | 1.21 | [0.43;3.41] | 73.7 | 4 | 1.05 | [0.33;3.31] | 62.7 |
167 genes | Loss | 7 (9.7%) | 4 | 10.9 | [3.10;38.6] | 0 | 4 | 5.33 | [1.63;17.5] | 22.2 |
p*=0.007 | p**< 0.001 | p*=0.05 | p**=0.007 | |||||||
chr19q13.32-q13.33 | Normal | 47 (66.2%) | 17 | 1 | 66.8 | 12 | 1 | 66.7 | ||
chr19:52,114,272-56,657,958 | Gain | 16 (22.5%) | 1 | 0.17 | [0.02;1.30] | 91.7 | 3 | 0.77 | [0.22;2.75] | 80.4 |
285 genes | Loss | 8 (11.3%) | 4 | 5.04 | [1.55;16.4] | 26.3 | 4 | 4.36 | [1.33;14.2] | 23.8 |
Missing | 1 | |||||||||
p*=0.003 | p**<0.001 | p*=0.07 | p**=0.016 | |||||||