Figure 1

Copy number alteration (CNA) patterns. Gains are shown in green and losses in red. Boundaries of chromosomes are indicated by white and blue vertical areas. A: CNA frequency plot in the complete tumor set. The grey horizontal bar indicates the 35% of tumors affected threshold. B: CNA frequency plots in different disease stages: Ad: adenomas, S1PT: Stage 1 Primary Tumors, S2PT: Stage 2 Primary Tumors, S3PT: Stage 3 Primary Tumors, S4PT: Stage 4 Primary Tumors, MT: metastases. C: significant differences between sequential steps of disease progression. assMT: depicts metastases associated to its cognate primary tumor.