Table 3 Correlation between COL1A1 mRNA expression and clinicopathological features

Age

≥65 years / <65 years

7 / 6

16 / 19

0.620

Sex

female / male

3 / 10

2 / 33

0.100

Virus

HCV / HBV / none

11 / 2 / 0

27 / 5 / 3

0.374

Child classification

B / A

2 / 11

3 / 32

0.507

Liver damage score

B / A

9 / 4

10 / 25

0.011

Tumor size

≥50 mm / <50 mm

3 / 10

10 / 25

0.700

Tumor number

multiple / solitary

4 / 9

13 / 22

0.685

Differentiation

poor / mod / well

0 / 12 / 1

1 / 30 / 4

0.699

Growth type

invasive / expansive

1 / 12

4 / 29

0.654

Capsule formation

present / absent

13 / 0

27 / 7

0.026

Septum formation

present / absent

10 / 2

26 / 7

0.732

Serosal invasion

present / absent

0 / 7

4 / 16

0.105

Vessel invasion

present / absent

1 / 12

9 / 26

0.176

Cirrhosis

present / absent

9 / 4

14 / 21

0.077

AFP

≥20 ng/ml / <20 ng/ml

10 / 3

18 / 17

0.115

Japanese stage

III + IV / I + II

4 / 9

12 / 23

0.820

TNM stage

III + IV / I + II

2 / 11

8 / 27

0.562

Methylation in tumor

present / absent

10 / 3

10 / 25

0.002