Table 1 Comparison of clinicopathological parameters in cases with or without ALK fusion

n

35

95

Age (years)

58.5

62.8

0.050

gender

   male

14

47

0.337

   female

21

48

smoking

   never

25

41

0.004

   ever

10

54

pStage

   I

20

60

0.532

   II-IV

15

35

differentiation grade

   wel

4

44

<0.001

   mod+por

31

51

Predominant subtype

   papillary

21

77

0.019

   Acinar

13

13

   Bronchioloalveolar

0

4

   solid with mucin

0

1

   signet

1

0

lymphatic invasion

   -

24

68

0.738

   +

11

27

Vessel invasion

   -

15

51

0.273

   +

20

44

TP53 mutation

   -

34

75

0.014

   +

1

20

EGFR mutation

   -

35

40

<0.0001

   +

0

55

KRAS mutation

   -

35

88

0.189

   +

0

7