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Table 2 Backward Cox’s proportional hazards regression analysis

From: Plasmacytoid variant of bladder cancer defines patients with poor prognosis if treated with cystectomy and adjuvant cisplatin-based chemotherapy

Variables in the equationb

 

B

SE

Wald

df

Significance

Exp(B)

95.0% Confidence interval for Exp(B)

lower

upper

Step 1

age

-.151

.232

.422

1

.516

.860

.546

1.356

gender

-.046

.281

.027

1

.870

.955

.550

1.657

pT

  

.432

3

.933

   

pT(1)

.146

.795

.034

1

.854

1.157

.244

5.495

pT(2)

.047

.464

.010

1

.919

1.048

.422

2.602

pT(3)

.185

.307

.364

1

.546

1.203

.659

2.196

Grade

.301

.351

.733

1

.392

1.351

.679

2.690

pN

-.468

.239

3.842

1

.050

.626

.392

1.000

M

  

.

0a

.

   

Adjuvant Chemo

  

2.790

2

.248

   

Adjuvant Chemo(1)

-.359

.538

.446

1

.504

.698

.243

2.005

Adjuvant Chemo(2)

.313

.233

1.806

1

.179

1.368

.866

2.160

Histo subtype

  

7.017

2

.030

   

Histo subtype(1)

1.095

.588

3.463

1

.063

2.988

.943

9.466

Histo subtype (2)

.261

.535

.237

1

.626

1.298

.455

3.703

Step 3

age

-.148

.221

.446

1

.504

.863

.559

1.331

gender

-.078

.275

.081

1

.776

.925

.539

1.585

Grade

.270

.335

.650

1

.420

1.310

.679

2.528

pN

-.436

.226

3.737

1

.053

.646

.415

1.006

Adjuvant Chemo

  

2.621

2

.270

   

Adjuvant Chemo(1)

-.360

.538

.448

1

.503

.697

.243

2.002

Adjuvant Chemo(2)

.294

.229

1.642

1

.200

1.342

.856

2.103

Histo subtype

  

7.587

2

.023

   

Histo subtype(1)

1.150

.581

3.920

1

.048

3.157

1.012

9.852

Histo subtype(2)

.298

.523

.325

1

.569

1.348

.483

3.759

Step 4

age

-.152

.221

.474

1

.491

.859

.558

1.324

Grade

.270

.336

.649

1

.421

1.310

.679

2.529

pN

-.437

.226

3.743

1

.053

.646

.415

1.006

Adjuvant Chemo

  

2.576

2

.276

   

Adjuvant Chemo(1)

-.375

.535

.490

1

.484

.687

.241

1.963

Adjuvant Chemo(2)

.285

.227

1.576

1

.209

1.330

.852

2.075

Histo subtype

  

7.516

2

.023

   

Histo subtype(1)

1.155

.580

3.959

1

.047

3.173

1.017

9.895

Histo subtype(2)

.317

.519

.372

1

.542

1.373

.496

3.797

Step 5

Grade

.292

.333

.766

1

.381

1.339

.697

2.574

pN

-.420

.224

3.522

1

.061

.657

.423

1.019

Adjuvant Chemo

  

2.442

2

.295

   

Adjuvant Chemo(1)

-.358

.535

.449

1

.503

.699

.245

1.993

Adjuvant Chemo(2)

.278

.226

1.506

1

.220

1.320

.847

2.056

Histo subtype

  

7.388

2

.025

   

Histo subtype(1)

1.144

.580

3.890

1

.049

3.141

1.007

9.792

Histo subtype (2)

.315

.519

.368

1

.544

1.370

.496

3.787

Step 6

pN

-.434

.223

3.771

1

.052

.648

.418

1.004

Adjuvant Chemo

  

2.328

2

.312

   

Adjuvant Chemo(1)

-.399

.532

.561

1

.454

.671

.237

1.905

Adjuvant Chemo(2)

.256

.224

1.298

1

.255

1.291

.832

2.004

Histo subtype

  

6.980

2

.030

   

Histo subtype (1)

1.145

.580

3.896

1

.048

3.143

1.008

9.800

Histo subtype(2)

.357

.516

.478

1

.489

1.429

.520

3.928

Step 7

pN

-.404

.222

3.307

1

.069

.667

.432

1.032

Histo subtype

  

8.123

2

.017

   

Histo subtype (1)

1.162

.580

4.015

1

.045

3.197

1.026

9.964

 

Histo subtype (2)

.302

.515

.344

1

.558

1.352

.493

3.709

  1. a. Degree of freedom is reduced because of constant or linear dependent covariates.
  2. b. Constant or linear dependent covariate M = 1; Significant values are marked in bold face.
  3. Exp(B) equals relative risk value (RR).
  4. Abbreviations and further information.
  5. Age: was grouped in group1 ≤ 60years and group 2 > 60 years.
  6. Gender: female (reference) and male groups.
  7. pT: tumor stage; pT(1)-tumor stage 1: pT(2) tumor stage 2; pT(3): tumor stage 3; (tumor stage 4 is reference).
  8. Grade: tumor grade: tumor grade 2 and tumor grade 3 (reference).
  9. pN: lymph node status, was grouped in group1=N0 and group2=N≥1 (N1, N2, N3, reference group).
  10. M: metastates status, group1without metastases (M0) and group 2 with metastases (M1), only one patient in group 2 therefore no calculations were performed.
  11. Adjuvant Chemo: Adjuvant Chemotherapy in 3 groups: Adjuvant Chemo(1) is treated with Gc = Gemcitabine, Cisplatin, Adjuvant Chemo(2) is treated with M-vec = Methotrexate, Vinblastine, Epirubicin, Cisplatin and the group treated with CM = Cisplatin, Methotrexate is the reference group.
  12. Histo subtype: Histology subtypes in 3 groups: Histo subtype(1) is the plasmacytoid urothelial carcinoma patients’ group, Histo subtype(2) is the conventional urothelial carcinoma patients’ group and the group with the micropapillary urothelial carcinoma patients is the reference group.
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BMC Cancer

ISSN: 1471-2407

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