Figure 3
Comparison of aberrant methylations of DMRs in hepatoblastoma. (A) Comparison of the numbers of aberrantly hypomethylated (blue bars) and hypermethylated (red bars) DMRs. Hypomethylation, but not hypermethlation, was observed in adjacent normal tissues. Hypermethylation was observed more frequently than hypomethylation in tumors compared to adjacent normal tissues. (B) Comparison of the frequencies of aberrant methylations between the paternally methylated DMRs (black bars) and the maternally methylated DMRs (white bars). Left and right panels indicate hypomethylation and hypermethylation, respectively. There was no significant difference in both hypomethylation and hypermethylation. (C) Comparison of the frequencies of aberrant methylations between gametic DMRs (yellow bars) and somatic DMRs (green bars). Left and right panels indicate hypomethylation and hypermethylation, respectively. Hypermethylation was observed more frequently at gametic DMRs with statistically significant difference in tumors compared to control livers. The frequencies were compared in (B) and (C) because of the difference in the total numbers of DMRs in the two categories compared; that is, the paternal and the maternal DMRs or the gametic and the somatic DMRs. The asterisks indicated significant difference. The p values are shown above the comparisons. b: binomial test, c: chi squared test.