Table 4 Toxicity profiles of AC/SD chemotherapy
NCI-CTC AE grade | |||||||
|---|---|---|---|---|---|---|---|
Toxicities | G1 | G2 | G3 | G4 | G5 | ≥G3 (%) | |
Hematologic toxicity (by cycle) | |||||||
Neutropenia | 2/1 | 1/3 | 6/6 | 6/9 | 0/0 | 12/15 (6.2/8.7) | |
Febrile neutropenia | 0/0 | 0/0 | 6/4 | 0/1 | 0/0 | 6/5 (3.1/2.9) | |
Anemia | 0/0 | 0/0 | 0/1 | 2/0 | 0/0 | 2/1 (1.0/0.6) | |
Non-hematologic toxicity (by patient) | |||||||
Epigastric pain | 7/15 | 3/2 | 0/6 | 0/0 | 0/0 | 0/6 (0/12.2) | |
Nausea | 19/11 | 8/4 | 1/2 | 0/0 | 0/0 | 1/2(2.0/4.1) | |
Vomiting | 8/9 | 4/3 | 1/2 | 0/0 | 0/0 | 1/2 (2.0/4.1) | |
Stomatitis/mucositis | 12/14 | 2/10 | 0/2 | 0/0 | 0/0 | 0/2 (0/4.1) | |
Infection | 0/0 | 1/1 | 1/0 | 0/1 | 0/1 | 1/2(2.0/4.1) | |
Increased ALT | 0/0 | 0/2 | 1/2 | 0/0 | 0/0 | 1/2 (2.0/4.1) | |
Myalgia | 6/13 | 1/7 | 0/1 | 0/0 | 0/0 | 0/1 (0/2.0) | |
Diarrhea | 2/4 | 2/2 | 0/1 | 0/0 | 0/0 | 0/1 (0/2.0) | |
Hand-foot syndrome | 0/1 | 0/3 | 0/1 | 0/0 | 0/0 | 0/1 (0/2.0) | |
Anorexia | 18/10 | 3/9 | 0/0 | 0/0 | 0/0 | 0/0 (0/0) | |
Constipation | 9/8 | 1/7 | 0/0 | 0/0 | 0/0 | 0/0 (0/0) | |
Arthralgia | 1/2 | 1/3 | 0/0 | 0/0 | 0/0 | 0/0 (0/0) | |
Peripheral neuropathy | 2/6 | 0/3 | 0/0 | 0/0 | 0/0 | 0/0 (0/0) | |
Edema | 1/9 | 0/1 | 0/0 | 0/0 | 0/0 | 0/0 (0/0) | |
Fatigue | 16/0 | 0/1 | 0/0 | 0/0 | 0/0 | 0/0 (0/0) | |