Figure 2From: Small-cell lung cancer with a rare epidermal growth factor receptor gene mutation showing “wax-and-wane” transformation Histopathology of combined small-cell lung cancer. A) Transbronchial lung biopsy from the primary lesion shows adenocarcinoma (hematoxylin and eosin staining, marked with arrow). The insets show that this tumor is positive for TTF-1 and negative for synaptophysin and chromogranin. B) Another slice from the same biopsy specimen shows small-cell lung cancer (hematoxylin and eosin staining, marked with arrow). The insets show that this tumor is positive for TTF-1, synaptophysin, and chromogranin. chr, chromogranin; syn, synaptophysin; TTF, TTF-1.Back to article page