Table 3 Prognostic/predictive factors at univariate analysis
Predictive for survival | N | HR | 95% CI | Median survival (months) | 2-sided P value |
|---|---|---|---|---|---|
AREG mRNA (25th percentile) | 0.47 | 0.31-0.70 | 0.0002 | ||
High | 124 | 29 | |||
Low | 40 | 16 | |||
EREG mRNA (75th percentile) | 0.45 | 0.28-0.72 | 0.0009 | ||
High | 39 | 36 | |||
Low | 117 | 23 | |||
BRAF | 8.1 | 3.44-19.0 | 0.00005 | ||
Mutation | 6 | 12 | |||
Wild type | 208 | 28 | |||
KRAS codon 12 | 1.62 | 1.10-2.38 | 0.014 | ||
Mutation | 44 | 19 | |||
Wild type | 129 | 29 | |||
Predictive for Response | Odds Ratio for Response | 95% CI | 2-sided P | ||
AREG mRNA at 25th percentile | 1.59 | 0.67-3.77 | 0.29 | ||
High vs. Low | |||||
EREG mRNA at 75th percentile | 2.26 | 1.04-4.91 | 0.04 | ||
High vs. Low |