Figure 5
From: CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α
Inhibiting CXCR4 in glioma cells that are knocked down for CXCR7 does not further reduce levels of SDF-1α-induced phosphorylation of ERK1/2 and Akt. shRNA-infected LN229 and LN308 glioma cells were exposed to SDF-1α for 15 min in the presence or absence of 100 nM of AMD3100 and analyzed for total and phosphorylated ERK1/2 and Akt by Western blot analysis. Data represent one of two independent experiments.