Figure 2
Pretreating MCF-7 or MDA-MB-231 with T 3 enhanced the sensitivity of breast cancer cells to 5-Fu and Taxol. (A) After using 4 ng/ml T3 to pretreat MCF-7 for 24 h, the inhibition ratio was higher in MCF-7 pretreated with T3, compared with MCF-7 with 5-Fu only, without T3 pretreatment, * P<0.05. (B) The inhibition ratio was higher in MDA-MB-231 pretreated with T3, compared with those with 5-Fu only, without T3 pretreatment, * P<0.05. (C&D) MCF-7 pretreated with T3 for 24 h showed significantly increased proportion of cells in S phase, and significantly decreased proportion of cells in G0-G1 phase, both compared with those of MCF-7 without T3 pretreatment, * P<0.05. (E&F) After using 24 ng/ml T3 to pretreat MCF-7 or MDA-MB-231 for 24 h, the inhibition ratio was higher in cancer cells pretreated with T3, compared with those with Taxol only, without T3 pretreatment, * P<0.05.