Interrogating differences in expression of targeted gene sets to predict breast cancer outcome

Andres, Sarah A; Brock, Guy N; Wittliff, James L

doi:10.1186/1471-2407-13-326

BMC Cancer

Table 2 Summary statistics for gene expression levels among the patient population

From: Interrogating differences in expression of targeted gene sets to predict breast cancer outcome

		Mortality			Recurrence
Name^Ϯ	Median (Q25, Q75)	HR (95% CI)	P-value	Adj P-value	HR (95% CI)	P-value	Adj P-value
RABEP1	-0.27 (-1.43, 1.05)	0.77 (0.67, 0.87)	0.000	0.011	0.79 (0.7, 0.9)	0.000	0.042
PGR*	0.38 (-2.3, 3.09)	0.91 (0.86, 0.95)	0.000	0.014	0.92 (0.87, 0.97)	0.001	0.042
NAT1*	2.15 (-0.42, 4.89)	0.87 (0.8, 0.94)	0.001	0.020	0.88 (0.81, 0.96)	0.002	0.058
PTP4A2	-0.35 (-1.4, 0.95)	0.76 (0.65, 0.89)	0.001	0.020	0.79 (0.68, 0.93)	0.004	0.071
SLC39A6*	-0.38 (-2.45, 1.69)	0.87 (0.8, 0.94)	0.001	0.020	0.87 (0.81, 0.95)	0.001	0.042
ESR1*	4.27 (-0.96, 5.84)	0.9 (0.85, 0.96)	0.001	0.021	0.92 (0.87, 0.98)	0.006	0.090
EVL	0.68 (-0.56, 2.31)	0.8 (0.69, 0.91)	0.001	0.022	0.85 (0.75, 0.97)	0.019	0.241
TBC1D9*	0.15 (-1.87, 2.31)	0.89 (0.83, 0.96)	0.001	0.022	0.9 (0.84, 0.97)	0.004	0.071
FUT8	-0.51 (-1.69, 0.68)	0.82 (0.73, 0.93)	0.002	0.026	0.82 (0.72, 0.92)	0.001	0.042
SCUBE2	2.04 (-0.95, 4.18)	0.89 (0.83, 0.96)	0.002	0.028	0.91 (0.85, 0.98)	0.009	0.131
GATA3	0.87 (-1.82, 2.15)	0.89 (0.81, 0.97)	0.007	0.080	0.9 (0.83, 0.99)	0.022	0.256
MELK	-2.53 (-3.47, -1.54)	1.24 (1.06, 1.46)	0.008	0.088	1.19 (1.02, 1.39)	0.031	0.337
TCEAL1	0.45 (-0.95, 1.74)	0.83 (0.72, 0.96)	0.012	0.124	0.87 (0.76, 1)	0.057	0.502
XBP1	2.69 (0.73, 3.66)	0.87 (0.78, 0.98)	0.021	0.197	0.89 (0.8, 1)	0.055	0.502
PLK1	-2.5 (-3.32, -1.56)	1.25 (1.02, 1.52)	0.029	0.250	1.2 (0.99, 1.45)	0.058	0.502
IL6ST	-2.94 (-4.84, -0.45)	0.92 (0.85, 1)	0.045	0.363	0.95 (0.88, 1.02)	0.166	1.000
DSC2	0.31 (-0.52, 1.71)	1.1 (0.98, 1.24)	0.099	0.759	1.09 (0.97, 1.22)	0.170	1.000
CX3CL1	0.86 (-0.29, 2)	1.11 (0.97, 1.27)	0.123	0.890	1.07 (0.94, 1.22)	0.314	1.000
ATAD2	-1.18 (-1.87, -0.56)	1.08 (0.86, 1.35)	0.521	1.000	1.15 (0.92, 1.44)	0.230	1.000
BUB1	-3.1 (-4.23, -2.35)	1.05 (0.88, 1.24)	0.602	1.000	1.01 (0.86, 1.19)	0.869	1.000
CENPA	-2.18 (-3.06, -1.16)	1.07 (0.9, 1.28)	0.427	1.000	1.03 (0.86, 1.22)	0.780	1.000
CKS2	-1.89 (-3.32, -0.95)	0.99 (0.87, 1.13)	0.925	1.000	0.97 (0.85, 1.11)	0.678	1.000
GABRP*	3.08 (0.38, 5.36)	0.99 (0.93, 1.05)	0.698	1.000	0.97 (0.91, 1.03)	0.323	1.000
GMPS	-1.4 (-2.22, -0.64)	0.95 (0.79, 1.15)	0.601	1.000	0.88 (0.74, 1.06)	0.186	1.000
LRBA*	-1.71 (-3.27, 0.67)	0.99 (0.91, 1.09)	0.871	1.000	1 (0.92, 1.09)	0.986	1.000
MAPRE2	-1.84 (-2.84, -0.85)	1.04 (0.88, 1.23)	0.647	1.000	0.99 (0.84, 1.17)	0.921	1.000
MCM6	-2.27 (-3.27, -1.43)	0.96 (0.82, 1.14)	0.655	1.000	0.95 (0.81, 1.11)	0.545	1.000
PFKP	-2.45 (-3.42, -1.46)	1.13 (0.96, 1.33)	0.152	1.000	1.05 (0.9, 1.23)	0.539	1.000
ST8SIA1	-0.67 (-1.59, 0.58)	1.02 (0.89, 1.17)	0.795	1.000	1.02 (0.89, 1.17)	0.769	1.000
TPBG	0.68 (-0.38, 1.48)	0.89 (0.75, 1.05)	0.172	1.000	0.9 (0.76, 1.06)	0.201	1.000
TRIM29	-0.71 (-2.74, 1.03)	0.98 (0.9, 1.08)	0.734	1.000	0.98 (0.9, 1.07)	0.637	1.000
YBX1	-1.72 (-2.42, -1.12)	1.1 (0.88, 1.36)	0.413	1.000	1.04 (0.84, 1.29)	0.702	1.000

Univariate hazard ratios (HRs), 95% confidence intervals (CIs), and unadjusted/adjusted p-values for disease mortality and recurrence are included. Q25 = 25^th percentile, Q75 = 75^th percentile.
^ϮGenes ordered by adjusted p-value for mortality and then by gene name. *Genes which passed the permutation threshold for significance in the multivariable model, for both mortality and recurrence.

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ISSN: 1471-2407

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