Table 1 Main characteristics of studies included in the meta-analysis of the diagnostic accuracy of CTCs detection in gastric cancer
First author | Year of publication | Country of origin | Maker used | CTC/patients | CTC/controls | tp | fp | fn | tn | Patient age(years) mean(range) | Tumor histology | Tumor stage | Data about prognosis | Inclusion criteria | Detection method |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aihara | 1997 | Japan | Keratin 19 | 0/49 | 0/50 | 0 | 0 | 49 | 50 | NR | NR | I-IV | No | UICC | RT-PCR |
Bertazza | 2009 | Italy | Survivin | 69/70 | 0/20 | 69 | 0 | 1 | 20 | 68(28–90)†| Yes | I-IV | Yes | UICC | qRT-PCR |
CK19 | 68/70 | 0/20 | 68 | 0 | 2 | 20 | |||||||||
CEA | 30/70 | 0/20 | 30 | 0 | 40 | 20 | |||||||||
VEGF | 27/70 | 0/20 | 27 | 0 | 43 | 20 | |||||||||
Cui | 2011 | China | piR-651 | 66/93 | 6/32 | 66 | 6 | 27 | 26 | preoperative:60 ± 17; postoperative:63 ± 14 | Yes | I-IV | Np | National Comprehensive Cancer Network clinical practice guideline of oncology | qRT-PCR |
piR-823 | 75/93 | 6/32 | 75 | 6 | 18 | 26 | |||||||||
Hiraiwa | 2008 | Japan | EpCAM | 17/41 | 0/41 | 17 | 0 | 24 | 41 | NR | Yes | I-IV | Yes | AJCC | Immunological |
Ikeguchi | 2005 | Japan | CEA | 0/59 | 0/15 | 0 | 0 | 59 | 15 | 66.3(26–86) | Yes | I-IV | Yes | Japanese Classification of Gastric Carcinoma | RT-PCR |
Ikeguchi | 2003 | Japan | CEA | 1/55 | 0/40 | 1 | 0 | 54 | 40 | 65.4 | Yes | I-IV | No | Japanese Classification of Gastric Carcinoma | RT-PCR |
CK19 | 0/55 | 0/40 | 0 | 0 | 55 | 40 | |||||||||
CK20 | 15/55 | 2/40 | 15 | 2 | 40 | 38 | |||||||||
Ito | 2010 | Japan | GFP | 27/27 | 0/80 | 27 | 0 | 0 | 80 | 56.1(39–76) | Yes | I-IV | No | AJCC | Immunological |
Koga | 2008 | Japan | CK19 | 8/69 | 0/14 | 8 | 0 | 61 | 14 | 65.7 | Yes | I-IV | No | Japanese Classification of Gastric Carcinoma | qRT-PCR |
CK20 | 10/69 | 0/14 | 10 | 0 | 59 | 14 | |||||||||
Majima | 2000 | Japan | CK19 | 5/52 | 0/14 | 5 | 0 | 47 | 14 | NR | NR | I-IV | Yes | Creteria of the UICC | RT-PCR |
CK20 | 5/52 | 1/14 | 5 | 1 | 47 | 13 | |||||||||
Noh | 1999 | Korea | CEA | 16/35 | 0/9 | 16 | 0 | 19 | 9 | 54.5(26–71) | Yes | I/III/IV | No | AJCC | RT-PCR |
Qiao | 2007 | China | CK20 | 9/40 | 0/20 | 9 | 0 | 31 | 20 | 62.2 | Yes | Â | No | NR | RT-PCR |
Ren | 2011 | China | EpCAM | 20/33 | 0/60 | 20 | 0 | 13 | 60 | NR | Yes | I-IV | No | AJCC | Immunological |
Uen | 2006 | China | c-Met | 32/52 | 2/36 | 32 | 2 | 20 | 34 | 60.0(34–84) | Yes | I-IV | Yes | AJCC | RT-PCR |
MUC1 | 37/52 | 3/36 | 37 | 3 | 15 | 33 | |||||||||
Wang | 2009 | China | MAGE-1 | 19/40 | 0/20 | 19 | 0 | 21 | 20 | 55.7(27–77) | Yes | I-IV | No | AJCC | RT-PCR |
MAGE-3 | 10/40 | 0/20 | 10 | 0 | 30 | 20 | |||||||||
Wu | 2006 | China | hTERT | 52/64 | 14/80 | 52 | 14 | 12 | 66 | 60.5(36–84) | Yes | I-IV | Yes | AJCC | RT-PCR |
CK19 | 50/64 | 12/80 | 50 | 12 | 14 | 68 | |||||||||
CEA | 53/64 | 19/80 | 53 | 19 | 11 | 61 | |||||||||
MUC1 | 54/64 | 13/80 | 54 | 13 | 10 | 67 | |||||||||
Wu | 2006 | China | hTERT | 26/42 | 0/30 | 26 | 0 | 16 | 30 | 60.2(34–84) | Yes | I-IV | Yes | AJCC | RT-PCR |
CK19 | 29/42 | 1/30 | 29 | 1 | 13 | 29 | |||||||||
CK20 | 26/42 | 1/30 | 26 | 1 | 16 | 29 | |||||||||
CEA | 33/42 | 0/30 | 33 | 0 | 9 | 30 | |||||||||
Yang | 2002 | China | CEA | 24/40 | 1/34 | 24 | 1 | 16 | 33 | 51.2(38–76) | Yes | I-IV | No | AJCC | RT-PCR |
Yeh | 1998 | China | CK19 | 7/34 | 0/33 | 7 | 0 | 27 | 33 | 57(31–81)†| Yes | I-IV | Yes | UICC | RT-PCR |
Zhang | 2007 | China | CEA | 4/45 | 0/13 | 4 | 0 | 41 | 13 | 60.5(42–78) | Yes | I-IV | No | UICC | RT-PCR |
Zhou | 2010 | China | miR-106a | 43/90 | 3/27 | 43 | 3 | 47 | 24 | male: 62.3; female:59.2 | Yes | NR | No | UICC | RT-PCR |
MiR-17 | 47/90 | 2/27 | 47 | 2 | 43 | 25 |