Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivomouse colon cancer model

BMC Cancer

Table 4 The effect of vitamin D analog (in the most effective dose, administered orally) alone or in combination with 5-FU on tumor growth and body weight of mice bearing subcutaneously MC38 colon cancer

Analog (AN)	5-FU	AN	TGI [%] on the 21st day of the experiment					Maximal decrease
			TGI [%] on the 21st day of the experiment					in body weight [%]
			5-FU	AN	5-FU + AN	%H TGI	Effect	5-FU	AN	5-FU + AN
PRI-2191	100 mg/kg	1 μg/kg	72	12	81	75	Synergism	2	5	15
PRI-2205	100 mg/kg	10 μg/kg	72	6	73	73	No effect	2	5	5

Vitamin D analog was administered orally (p.o.), three times a week.
AN Analog of vitamin D, TGI Tumor growth inhibition; %H TGI, Hypothetical tumor growth inhibition; Number of mice in each group - 8.
Mice bearing s.c. MC38 colon cancer cells were i.v. injected with 5-FU at a dose of 100 mg/kg/day from days 9 to 23 and/or vitamin D analogs: PRI-2191 at a dose of 1 μg/kg/day or PRI-2205 at a dose of 10 μg/kg/day. Both analogs were administrated p.o., three times a week from days 12 to 28.

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