Figure 2
From: Diagnostic markers of urothelial cancer based on DNA methylation analysis
Global DNA methylation alterations in UC. Supervised cluster analysis of 1,303 loci (784 genes) from bladder samples, using the Illumina GoldenGate methylation assay. N (n = 12) represents normal tissue from patients without urothelial cancer (UC); CN (n = 34) represents corresponding normal-appearing tissue from UC patients; Ta-T1 (n = 49) represents non-muscle-invasive bladder cancer; and T2-T4 (n = 38) represents muscle-invasive bladder cancer. No methylation is shown in blue, and increasing DNA methylation is shown in yellow. (a) UC-specific hypomethylated CpG sites, and (b) UC-specific hypermethylated CpG sites.