From: Inorganic phosphate and the risk of cancer in the Swedish AMORIS study
Cancer site (ICD-7) | n cases | Quartiles of Pi (mmol/L), HR (95% CI) | P-value for trend | Standardized Pi, HR (95% CI) | |||
---|---|---|---|---|---|---|---|
< 0.92 | 0.92 – 1.03 | 1.03 – 1.14 | ≥ 1.14 | ||||
Lip, oral cavity, pharynx (140–149) | 135 | 1.00 (Ref) | 1.12 (0.71 – 1.77) | 1.15 (0.71 – 1.86) | 1.28 (0.77 – 2.12) | 0.31 | 1.10 (0.93 – 1.30) |
Oesophagus (150) | 196 | 1.00 (Ref) | 1.23 (0.84 – 1.80) | 1.26 (0.84 – 1.89) | 1.43 (0.94 – 2.18) | 0.17 | 1.12 (0.98 – 1.28) |
Stomach (151) | 400 | 1.00 (Ref) | 1.10 (0.87 – 1.41) | 0.80 (0.60 – 1.07) | 1.07 (0.80 – 1.44) | 0.49 | 0.98 (0.88 – 1.09) |
Colorectal (153, 154) | 1929 | 1.00 (Ref) | 1.06 (0.94 – 1.18) | 0.95 (0.84 – 1.08) | 0.91 (0.79 – 1.05) | 0.07 | 0.95 (0.91 – 1.00) |
Liver, gallbladder (155) | 319 | 1.00 (Ref) | 1.15 (0.86 – 1.54) | 1.07 (0.78 – 1.47) | 1.38 (1.00 – 1.91) | 0.14 | 1.09 (0.98 – 1.22) |
Pancreas (157) | 427 | 1.00 (Ref) | 1.32 (1.03 – 1.71) | 1.27 (0.97 – 1.68) | 1.41 (1.05 – 1.88) | 0.02 | 1.11 (1.02 – 1.22) |
Larynx (161) | 143 | 1.00 (Ref) | 1.13 (0.72 – 1.77) | 1.33 (0.84 – 2.10) | 1.28 (0.78 – 2.10) | 0.24 | 1.11 (0.95 – 1.29) |
Lung (162) | 1396 | 1.00 (Ref) | 1.24 (1.07 – 1.42) | 1.22 (1.05 – 1.42) | 1.35 (1.15 – 1.58) | 0.002 | 1.10 (1.04 – 1.15) |
Prostate (177) | 5075 | 1.00 (Ref) | 1.01 (0.94 – 1.08) | 1.02 (0.94 – 1.10) | 0.98 (0.90 – 1.07) | 0.72 | 0.98 (0.95 – 1.01) |
Testis (178) | 159 | 1.00 (Ref) | 0.98 (0.60 – 1.58) | 0.97 (0.60 – 1.57) | 1.11 (0.70 – 1.75) | 0.62 | 1.02 (0.88 – 1.19) |
Kidney (180) | 525 | 1.00 (Ref) | 1.05 (0.84 – 1.32) | 1.14 (0.90 – 1.44) | 0.87 (0.66 – 1.15) | 0.49 | 1.03 (0.94 – 1.13) |
Bladder (181) | 1181 | 1.00 (Ref) | 0.99 (0.85 – 1.15) | 1.04 (0.89 – 1.21) | 1.02 (0.86 – 1.21) | 0.76 | 1.02 (0.96 – 1.08) |
Melanoma of skin (190) | 765 | 1.00 (Ref) | 1.02 (0.85 – 1.24) | 1.08 (0.89 – 1.32) | 1.01 (0.89 – 1.25) | 0.66 | 1.01 (0.94 – 1.09) |
Nonmelanoma of skin (191) | 772 | 1.00 (Ref) | 0.95 (0.80 – 1.14) | 0.90 (0.74 – 1.10) | 1.13 (0.91 – 1.39) | 0.46 | 0.98 (0.91 – 1.06) |
Brain/central nervous system (193) | 527 | 1.00 (Ref) | 1.03 (0.82 – 1.31) | 1.08 (0.84 – 1.37) | 1.06 (0.82 – 1.37) | 0.74 | 1.01 (0.92 – 1.10) |
Thyroid gland (194) | 69 | 1.00 (Ref) | 0.94 (0.45 – 1.98) | 1.76 (0.90 – 3.43) | 1.69 (0.85 – 3.38) | 0.04 | 1.15 (0.93 – 1.41) |
Other endocrine organ (195) | 215 | 1.00 (Ref) | 0.46 (0.31 – 0.66) | 0.44 (0.29 – 0.65) | 0.67 (0.47 – 0.96) | 0.03 | 0.87 (0.76 – 1.00) |
Bone (196) | 1690 | 1.00 (Ref) | 1.15 (1.02 – 1.31) | 1.15 (1.01 – 1.32) | 1.25 (1.08 – 1.10) | 0.002 | 1.06 (1.01 – 1.11) |
Soft tissues (197) | 126 | 1.00 (Ref) | 1.48 (0.93 – 2.37) | 1.13 (0.67 – 1.92) | 1.42 (0.83 – 2.42) | 0.32 | 1.11 (0.95 – 1.30) |
Non-Hodgkin’s lymphoma (200, 202) | 613 | 1.00 (Ref) | 1.24 (1.00 – 1.52) | 1.06 (0.84 – 1.33) | 1.22 (0.96 – 1.55) | 0.25 | 1.08 (1.00 – 1.17) |
Hodgkin’s lymphoma (201) | 62 | 1.00 (Ref) | 0.98 (0.82 – 1.18) | 1.01 (0.99 – 1.02) | 1.45 (0.95 – 2.22) | 0.51 | 0.92 (0.71 – 1.20) |
Multiple myeloma (203) | 259 | 1.00 (Ref) | 1.31 (0.96 – 1.77) | 0.84 (0.57 – 1.21) | 1.20 (0.83 – 1.74) | 0.82 | 1.02 (0.90 – 1.16) |
Leukemia (204–207) | 398 | 1.00 (Ref) | 0.88 (0.68 – 1.13) | 0.79 (0.59 – 1.04) | 0.85 (0.63 – 1.14) | 0.12 | 0.98 (0.89 – 1.09) |
Other cancer 1 | 865 | 1.00 (Ref) | 1.15 (0.96 – 1.38) | 1.23 (1.02 – 1.49) | 1.38 (1.13 – 1.68) | 0.003 | 1.10 (1.03 – 1.18) |