Figure 2

Examples of individual neuroblastoma profiles within genetic subgroups. (A) MNA^not11q-; (B) 11q-^notMNA; (C) combined MNA and segmental 11q loss; (D) neither MNA nor segmental 11q loss; (E) shows an expanded segment of chromosome 12 in panel (D). Amplified genes of particular oncogenic interest are indicated. Each individual clone was assigned a copy number class as follows: i) balanced: two alleles (blue dots); ii) gained: presence of three (red) or more (pink dots) alleles; or iii) deleted: hemizygous deletions (green dots). No homozygous deletions were found in these tumors. Black arrows indicate MNA amplification, 11q loss or other amplifications.