Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study

BMC Cancer

Table 3 Risk of ductal and luminal breast cancer associated with SNPs in TLR or NFκB pathway genes

	Maj/Min Allele	Controls (n = 807)			Ductal (n = 565)			OR	95% CI		Gene wideP	Luminal (n = 744)			OR	95% CI		Gene wide P
		0	1	2	0	1	2					0	1	2
MAP3K1											0.01							0.003
rs889312	A/C	434	318	49	281	220	60	1.24	1.04	1.46		361	301	77	1.27	1.08	1.48
MMP9											0.02							0.02
rs17576	A/G	366	357	78	216	276	67	1.24	1.05	1.46		296	340	100	1.23	1.06	1.43
rs2274756	G/A	611	178	12	424	129	8	1.03	0.82	1.29		541	183	15	1.17	0.95	1.44
rs3918262	A/G	518	246	31	327	195	35	1.29	1.08	1.56		444	248	40	1.20	1.01	1.43
TANK											0.002							0.004
rs17705608	A/G	263	404	134	230	256	75	0.78	0.67	0.92		284	358	97	0.82	0.71	0.95
rs7568498	A/C	558	208	35	385	161	15	0.98	0.80	1.19		495	223	21	1.04	0.87	1.25
rs1921310	A/G	449	303	49	347	191	23	0.80	0.67	0.96		446	261	32	0.84	0.71	1.00
rs1267074	T/A	397	310	94	251	253	56	1.07	0.91	1.26		326	336	76	1.09	0.94	1.27
rs1267034	A/G	623	159	19	412	137	12	1.19	0.95	1.48		546	176	17	1.17	0.96	1.44
rs7309	A/G	196	392	212	179	264	118	0.78	0.67	0.91		216	375	148	0.80	0.69	0.92
TLR9											0.14							0.09
rs352140	A/G	219	391	191	180	268	113	0.85	0.73	0.99		234	359	146	0.85	0.74	0.98
rs187084	A/G	302	362	137	190	254	117	1.16	1.00	1.34		254	337	148	1.13	0.98	1.30

^aAll models are log-additive and adjusted for continuous linear age at reference.

ISSN: 1471-2407