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Table 2 Evaluation of hypoxia in feline SCC before and after anti-angiogenic therapy

From: Evaluation of hypoxia in a feline model of head and neck cancer using 64Cu-ATSM positron emission tomography/computed tomography

Column1

Diagnosis

Location

Maximum dimension (cm)

Tmax/M

Tav/M

pO2 #1 (mmHg)

pO2 #2 (mmHg)

PO2 #3 (mmHg)

Cat 8a

SCC

Mandible

4.41

11

3.05

2.2

26

2.6

Cat 8b

SCC

Mandible

4.41

11.8

3.16

24

2.8

2.6

Cat 9a

SCC

Maxilla

4.18

4.25

1.83

0.3

0.1

0.6

Cat 9b

SCC

Maxilla

4.06

5

1.73

14

19

20

  1. Cat 8 was treated with Anginex, an anti-vascular peptide, while cat 9 was treated with toceranib, a VEGFR2 inhibitor. 64Cu-ATSM PET/CT and intratumoural fluorescent O2 measurements were performed 7 days apart, with treatment occurring in the intervening interval. Lower case letter a and b indicates pre- and post-treatment data, respectively. The location of the mass, maximum dimension of the mass, Tmax/M, Tav/M and pO2 in three tumor regions are provided. HNSCC = head and neck squamous cell carcinoma.