|  | OS |  | TTR | ||||
---|---|---|---|---|---|---|---|---|
 |  |  | Multivariate |  |  | Multivariate | ||
Factors | Univariate p | HR | 95% Cl | p | Univariate p | HR | 95% Cl | p |
Sex: Male vs Female | 0.870 | Â | Â | NA | 0.547 | Â | Â | NA |
Age: < 50 vs >50 | 0.241 | Â | Â | NA | 0.131 | Â | Â | NA |
HBsAg: positive vs negative | 0.166 | Â | Â | NA | 0.178 | Â | Â | NA |
Cirrhosis: yes vs no | 0.077 | Â | Â | NA | 0.135 | Â | Â | NA |
serum AFP (ng/ml): ≤ 20 vs > 20 | 0.005 |  |  | NA | 0.031 |  |  | NA |
Child-pugh: A vs B vs C | 0.284 | Â | Â | NA | 0.225 | Â | Â | NA |
TNM: I vs II vs III-IV | 0.000 | 1.534 | 1.262-1.864 | 0.000 | 0.000 | 1.496 | 1.243-1.801 | 0.000 |
tumor differentiation: | ||||||||
  well vs moderate vs Poor | 0.025 |  |  | NS | 0.236 |  |  | NA |
vascular invasion: yes vs no | 0.002 | Â | Â | NS | 0.013 | Â | Â | NA |
ACY1: low vs high | 0.930 | Â | Â | NA | 0.687 | Â | Â | NA |
SQSTM1: low vs high | 0.438 | Â | Â | NA | 0.932 | Â | Â | NA |
GPC3: low vs high | 0.001 | Â | Â | NS | 0.004 | Â | Â | NS |
AFP and GPC3 combination | ||||||||
  A-/G high vs A-/G low or A+/ G high vs A+/G low | 0.000 | 1.811 | 1.439-2.279 | 0.000 | 0.000 | 1.530 | 1.233-1.898 | 0.000 |