Table 3 Incidence of CTCAE Grade 3 and 4 adverse events (occurring in ≥ 2 patients), regardless of causality

Any event

17 (68)

14 (63.6)

5 (83.3)

36 (67.9)

Fatigue^†

1 (4)

4 (18.2)

1 (16.7)

6 (11.3)

Asthenia^†

1 (4)

1 (4.5)

2 (33.3)

4 (7.5)

Diarrhea ^†

1 (4)

2 (9.1)

1 (16.7)

4 (7.5)

Hypophosphatemia

2 (8)

2 (9.1)

0

4 (7.5)

ALT elevation^†

2 (8)

1 (4.5)

0

3 (5.7)

Dehydration

1 (4)

1 (4.5)

1 (16.7)

3 (5.7)

Hyperbilirubinemia

1 (4)

2 (9.1)

0

3 (5.7)

Hyponatremia

3 (12)

0

0

3 (5.7)

Arthralgia

1 (4)

0

1 (16.7)

2 (3.8)

Serum amylase elevated^†

1 (4)

1 (4.5)

0

2 (3.8)

Hypokalemia^†

0

2 (9.1)

0

2 (3.8)

Spinal cord compression

2 (8)

0

0

2 (3.8)