Table 5 Cox multivariate analysis of disease-free and overall survival by molecular subtypes
Recur | P-value | Death | P-value | |
|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
Luminal A | ||||
Mode of BC Detection | ||||
Screen Detected | 1.00 | 1.00 | ||
Symptomatic | 2.73 (1.05–7.13) | .03 | 4.2 (0.97–18.16) | .05 |
Tumor size | .91 | .72 | ||
T1 | 1.00 | 1.00 | ||
T2 | 1.11 (0.56–2.2) | .73 | 1.19 (0.51–2.78) | .74 |
T3–T4 | 1.09 (0.42–2.87) | .81 | 0.69 (0.18–2.58) | .52 |
No. of positive Lymph nodes | <.0001 | <.0001 | ||
All lymph nodes negative | 1.00 | 1.00 | ||
1–3 | 1.9 (0.81–4.47) | .12 | 2.84 (0.89–9.05) | .07 |
≥4 | 6.27 (3.05–12.91) | <.0001 | 9.69 (3.57–26.26) | <.0001 |
Luminal B | ||||
Mode of BC Detection | ||||
Screen Detected | 1.00 | 1.00 | ||
Symptomatic | 2.66 (0.59–11.88) | .21 | 2.79 (0.33–23.7) | .33 |
Tumor size | .4 | .05 | ||
T1 | 1.00 | 1.00 | ||
T2 | 1.05 (0.39–2.77) | .91 | 0.56 (0.11–2.92) | .53 |
T3–T4 | 2.61 (0.58–11.71) | .22 | 5.59 (1.03–30.22) | .04 |
No. of positive Lymph nodes | .12 | .74 | ||
All lymph nodes negative | 1.00 | 1.00 | ||
1–3 | 2.55 (0.82–7.88) | .01 | 0.81 (0.14–4.52) | .81 |
≥4 | 3.55 (1.02–12.42) | .04 | 1.66 (0.35–7.75) | .52 |
Non Luminal Her2+ | ||||
Mode of BC Detection | ||||
Screen Detected | 1.00 | 1.00 | ||
Symptomatic | 1.86 (0.19–18.18) | .72 | 1.43 (0.14–14.05) | .91 |
Tumor size | .03 | .09 | ||
T1 | 1.00 | 1.00 | ||
T2 | 1.77 (0.47–6.67) | .44 | 5.48 (1.02–29.2) | .05 |
T3–T4 | 8.62 (1.65–44.78) | .01 | 8.56 (1.05–69.9) | .04 |
No. of positive Lymph nodes | .81 | .42 | ||
All lymph nodes negative | 1.00 | 1.00 | ||
1–3 | 1.47 (0.38–5.6) | .84 | 0.41 (0.09–1.88) | .22 |
≥4 | 1.54 (0.34–7.05) | .51 | 1.07 (0.22–5.1) | .91 |
Triple Negative | ||||
Mode of BC Detection | ||||
Screen Detected | 1.00 | 1.00 | ||
Symptomatic | 0.14 (0.008–2.39) | .11 | n.e*. | |
Tumor size | .11 | .12 | ||
T1 | 1.00 | 1.00 | ||
≥T2 | 7.17 (1.15–44.72) | .03 | 7.41 (0.61–89.8) | .14 |
No. of positive Lymph nodes | .001 | .01 | ||
All lymph nodes negative | 1.00 | 1.00 | ||
All lymph nodes positive | 3.58 (3.65–7.76) | .001 | 4.85 (1.46–16.13) | .01 |