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Table 1 Synthesis of evidence regarding measurement properties: comparison of outcome measures

From: Functional capacity, physical activity and muscle strength assessment of individuals with non-small cell lung cancer: a systematic review of instruments and their measurement properties

Outcome measure

Reliability, measurement error and responsiveness

Criterion concurrent validity (gold standard)

Criterion predictive validity

Construct validity (hypothesis testing)

Functional capacity

    

6-minute walk test

x

x

8 studies [22–27, 39–41], predicts: survival, post-op outcomes (complications, LOS, 6MWT, HRQoL) and development of RP

1 study [26, 27], strongly correlated with RFT

12-minute walk test

x

x

x

x

Incremental-shuttle walk test

x

1 study [30], strongly correlated with CPET

2 studies [30, 64], predicts: survival and post-op outcomes

3 studies [30, 44, 64], moderately correlated with muscle strength; little, moderate and strong correlation with RFT; little correlation with mastery questionnaire

Endurance-shuttle walk test

x

x

x

x

Stair-climb test

x

1 study [29], strongly correlated with CPET

13 studies [21, 22, 32–39, 41–43], predicts: post-op outcomes (complications, LOS, cost) and survival

2 studies [20, 31], strong correlation between VO2peak and altitude reached; direct association between pre and post-op SCT results

Physical activity

    

Accelerometer

x

x

x

3 studies [46–51], strongly correlated with estimated EE and sleep; moderately correlated with depression, HRQoL and PS

Pedometer

x

x

x

1 study [53], moderately correlated with CPET

Muscle strength

    

Hand-held dynamometry

x

x

x

x

Hand-held dynamometry with pulley force sensor

1 study [52], very good intra-rater reliability; large SEM

x

x

x

Hand-grip dynamometry

1 study [28], moderate intra-rater reliability

x

x

x

Manual-muscle test

x

x

x

x

One-repetition maximum

x

x

x

x

Chair-stand test

x

x

x

1 study [53], moderately correlated with PS and fatigue

  1. Abbreviations: 6MWT, six-minute walk test; CPET, cardio-pulmonary exercise testing; EE, energy expenditure; HRQoL, health related quality of life; ICC, intraclass correlation coefficient; LOS, length of hospital stay; post-op, post-operative; pre-op, pre-operative; PS, Performance Status; RFT, respiratory function tests; RP, radiation pneumonitis; SCT, stair-climb test; SEM, standard error of measurement; VO 2 peak, peak oxygen consumption.
  2. x = not assessed.