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Table 2 The genotype distributions of MDM2 SNP309 in the cases with gastric carcinoma and healthy controls

From: A functional polymorphism T309G in MDM2 gene promoter, intensified by Helicobacter pylori lipopolysaccharide, is associated with both an increased susceptibility and poor prognosis of gastric carcinoma in Chinese patients

 

Controls (n = 574)

Patients (n = 574)

Crude OR (95% CI)

Pvalue

Adjusted OR (95% CI)†

Pvalue

Genotype

      

  T/T

34.7%

30.1%

1.00

   

  T/G

51.6%

45.3%

1.01 (0.78-1.32)

0.94

1.01 (0.78-1.31)

0.95

  G/G

13.7%

24.6%

2.05 (1.46-2.89)

< 0.01

2.06 (1.46-2.90)

< 0.01

Recessive model

      

  T carriers

86.3%

75.4%

1.00

   

  G/G

13.7%

24.6%

2.04 (1.51-2.77)

< 0.01

2.05 (1.51-2.78)

< 0.01

Dominant model

      

  T/T

31.2%

30.1%

1.00

   

  G carriers

68.8%

69.9%

1.23 (0.96-1.58)

0.10

1.23 (0.96-1.58)

0.10

  1. †Adjusted for age, sex, and H. pylori infection.
  2. Abbreviations: OR, odds ratio; CI, confidence interval.