Table 1 Study treatment doses
Phase A | Phase B | |
|---|---|---|
XELOX | Oxaliplatin: 130 mg/m2 iv day 1 | |
Every 3 weeks | Capecitabine: 1000 mg/m2 po twice daily days 1 to 14 | |
Bevacizumab: 7.5 mg/kg iv day 1 | ||
mFOLFOX6 | Oxaliplatin: 85 mg/m2 iv day 1 | |
Every 2 weeks | Leucovorin*: 400 mg/m2 iv day 1 | |
Fluorouracil: 400 mg/m2 iv day 1 | ||
Fluorouracil: 2400 mg/m2 continuous iv infusion over 46 hours day 1 | ||
Bevacizumab: 5.0 mg/kg iv day 1 | ||
FOLFIRI | Irinotecan: 180 mg/m2 iv day 1 | |
Every 2 weeks | Leucovorin*: 400 mg/m2 iv day 1 | |
Fluorouracil: 400 mg/m2 iv day 1 | ||
Fluorouracil: 2400 mg/m2 continuous iv infusion over 46 hours day 1 | ||
Bevacizumab: 5.0 mg/kg iv day 1 |