Table 3 Serum miRNAs in ovarian cancer

2 cancer

unknown

IV

1 mL serum

microarray (custom)

Clustered with other cancers and separate from normals

[32]

9 cancer

Mixed, 60% serous

I-IV

250uL serum

TaqMan qRT-PCR array

21 differentially expressed miRNA including miR-21, 92, 93, 29a, 126

[27]

4 normal

----

19 cancer

Mixed, 60% serous

I-IV

250uL serum

TaqMan qRT-PCR Assays (normalizer: miR-142-3p)

Increased in cancer versus normal: miR-21, 92, 93, 29a, 126

[27]

11 normal

----

4 cancer

serous

IV

Matched tumor and serum (exosomes from 2.5 mL serum)

microarray (custom)

Similar levels between tumor and serum suggesting a tumor origin for: miR-21, 141, 200a, 200b, 200c, 203, 205

[15]

30 cancer

serous

I (10)

Exosomes from 2.5 mL serum

microarray (custom)

Increased in cancer versus benign: miR-21, 141, 200a, 200b, 200c, 203, 205, 214, 215

[15]

II (10)

III (10)

10 benign

adenoma

----

28 cancer

Serous

II-IV

500 uL serum

TaqMan qRT-PCR Assays (normalizer: miR-103)

Increased in cancer versus normal: miR-200a, 200b, 200c

This study

28 normal

Age-matched

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