Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon

BMC Cancer

Table 5 Numbers of pathways displaying significant tumor-associated dysregulation in RS analysis of the N vs CRC data set and in independent validation data sets I and II

Differential regulation in CRCs^†	N vs CRC	V-set I	V-set II	Overlap‡
				N vs CRC and V-set I	N vs CRC and V-set II
No. upregulated pathways	33	107	157	24 (73%) - *1.1x10^-16	27 (82%) - *3.3x10^-16
No. downregulated pathways	25	73	58	14 (56%) - *4.6x10^-10	9 (36%) - *1.1x10^-8

^† No. of pathways found dysregulated by RS with p-values < 0.05.
‡ No. (%) of pathways dysregulated in N vs. CRC data set that were similarly dysregulated in the indicated V-set.
* p-values computed by Fisher’s exact test.

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