Table 3 Biological pathways displaying down-regulation (compared with normal mucosa) in SPLs, LPLs, and CRCs

1) BIOCARTA AT1R PATHWAY

50

0.047

-

-

2) BIOCARTA BIOPEPTIDES PATHWAY

81

0.027

-

-

3)BIOCARTA IL3 PATHWAY

20

0.044

-

-

4) KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION

51

0.029

-

-

5) KEGG CHEMOKINE SIGNALING PATHWAY

216

0.042

-

-

6) KEGG GAP JUNCTION

100

0.039

-

-

7) KEGG MAPK SIGNALING PATHWAY

400

0.047

-

-

8) KEGG VASCULAR SMOOTH MUSCLE CONTRACTION

152

0.037

-

-

9) REACTOME FORMATION OF PLATELET PLUG

236

0.017

-

-

10) REACTOME FRS2 MEDIATED ACTIVATION

23

0.049

-

-

11) REACTOME HEMOSTASIS

348

0.024

-

-

12) REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS

256

0.046

-

-

13) REACTOME NRAGE SIGNALS DEATH THROUGH JNK

61

0.041

-

-

14) REACTOME PLATELET ACTIVATION

208

0.018

-

-

15) REACTOME RHO GTPASE CYCLE

132

0.046

-

-

16) REACTOME SEMAPHORIN INTERACTIONS

89

0.031

-

-

17) SA PTEN PATHWAY

27

0.027

-

-

18) REACTOME CAM PATHWAY

32

-

0.042

-

19) REACTOME G ALPHA Z SIGNALLING EVENTS

13

-

0.04

-

20) REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA

23

-

0.037

-

21) REACTOME G PROTEIN ACTIVATION

34

-

0.02

-

22) REACTOME NEURORANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL

115

-

0.035

-

23) BIOCARTA NUCLEARRS PATHWAY

22

-

-

0.009

24) KEGG ASCORBATE AND ALDARATE METABOLISM

19

-

-

0.008

25) KEGG DRUG METABOLISM CYTOCHROME P450

71

-

-

0.017

26) KEGG DRUG METABOLISM OTHER ENZYMES

51

-

-

0.045

27) KEGG LONG TERM POTENTIATION

94

-

-

0.024

28) KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450

69

-

-

0.018

29) KEGG NICOTINATE AND NICOTINAMIDE METABOLISM

26

-

-

0.047

30) KEGG PENTOSE AND GLUCURONATE INTERCONVERSIONS

24

-

-

0.009

31) KEGG NITROGEN METABOLISM

28

-

-

0.024

32) KEGG RETINOL METABOLISM

59

-

-

0.028

33) KEGG STARCH AND SUCROSE METABOLISM

54

-

-

0.014

34) REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS

62

-

-

0.049

35) REACTOME ETHANOL OXIDATION

8

-

-

0.012

36) REACTOME GLUCURONIDATION

15

-

-

0

37) REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION

9

-

-

0.039

38) REACTOME PHASE II CONJUGATION

62

-

-

0.036

39) BIOCARTA HDAC PATHWAY

44

0.022

0.041

-

40) KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES

37

0.041

0.037

-

41) REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING

37

0.022

0.01

-

42) REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1

31

0.01

0.01

-

43) REACTOME ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12

24

0.028

0.021

-

44) REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION

42

0.046

0.028

-

45) REACTOME GLUCAGON TYPE LIGAND RECEPTORS

39

0.042

0.036

-

46) REACTOME GS ALPHA MEDIATED EVENTS IN GLUCAGON SIGNALLING

30

0.015

0.012

-

47) REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA

30

0.034

0.027

-

48) REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS

18

0.045

0.042

-

49) REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS

14

0.049

0.018

-

50) REACTOME OTHER SEMAPHORIN INTERACTIONS

25

0.005

0.005

-

51) REACTOME PLATELET ACTIVATION TRIGGERS

73

0.028

0.047

-

52) REACTOME SIGNAL AMPLIFICATION

39

0.007

0.005

-

53) REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS

28

0.019

0.016

-

54) REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR

26

0.007

0.003

-

55) KEGG GNRH SIGNALING PATHWAY

150

0.017

-

0.008

56) BIOCARTA STATHMIN PATHWAY

34

-

0.034

0.009

57) BIOCARTA PGC1A PATHWAY

37

0.005

0.011

0.008

58) KEGG PPAR SIGNALING PATHWAY

86

0.026

0.034

0.044

59) KEGG PROXIMAL TUBULE BICARBONATE RECLAMATION

25

0.003

0.003

0.011

60) KEGG SULFUR METABOLISM

18

0.047

0.03

0.038

61) REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY

78

0.005

0.006

0.006

62) REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS

23

0.011

0.012

0.022

63) REACTOME P2Y RECEPTORS

18

0.009

0.01

0.036