A. Cells with extensive junctional communication | ||||||
---|---|---|---|---|---|---|
Cell line | Treatmentα | Srcβ(%) | Stat3β(%) | GJICγ | ||
 |  |  | 50% | 100+3d | 90% | 100+3d |
E10 | - | 6±1 | 9±3 | 26±9 | 1.5±0.5 | 6.0±1 |
“ | DMSO | 6±1 | 9±3 | 30±8 | - | 6.0±1 |
“ | CPA7 | 5±1 | 2±1.1 | 3±1 | - | 0.2±0.1 |
“ | sh-Stat3 | N/A | 6±1.1 | 8±2 | - | 1.0±0.2 |
QU-DB | - | 7±1 | 10±2 | 20±4 | 1±0.2 | 6.3±1 |
“ | DMSO | 7±1 | 10±2 | 22±3 | - | 6.3±1 |
“ | CPA7 | 5±1 | 2±0.5 | 2±0.5 | - | 0.2±0.1 |
“ | sh-Stat3 | N/A | 5±3 | 8±2 | - | 0.8±0.2 |
SK-LuCi6 | - | 5±1 | 8±2 | 21±4 | 1.8±0.2 | 6.5±1 |
“ | DMSO | 5±1 | 8±2 | 20±5 | - | 6.5±1 |
“ | CPA7 | 5±1.2 | 2.8±1.25 | 3±1 | - | 0.3±0.1 |
“ | sh-Stat3 | N/A | 6±2 | 4±0.5 | - | 1±0.2 |
“ | Jak inhib.1 | 5.2±0.3 | 4.2±1.1 | 5±0.5 | - | 0.5±0.2 |
“ | Stat3C | 5.1±1 | 22±9 | 97±10 | - | 8±1 |
B. Cells expressing activated Src | ||||||
A549 | - | 95±11 | 93±12 | 320±32 | 0.1 ±0.1 | 0.3 ±0.1 |
“ | DMSO | 95±11 | 93±12 | 320±32 | - | 0.3 ±0.1 |
“ | CPA7 | 93±10 | 8±1 | 12±2 | - | 0.1 ±0.1 |
“ | sh-Stat3 | N/A | 12±3 | 11±4 | - | 0.1±0.1 |
E10- Src | DMSO | 98±12 | 98±15 | 350±28 | - | 0.4 ±0.2 |
“ | CPA7 | 95±11 | 5±1 | 15±4 | - | 0.1 ±0.1 |
“ | sh-Stat3 | N/A | 9±3 | 20±3 | - | 0.1±0.1 |
SK-LuCi6- Src | DMSO | 100±12 | 100±12 | 420±33 | - | 0.2±0.1 |
“ | CPA7 | 98±10 | 3±1 | 9±1 | - | 0.1 ±0.1 |
“ | sh-Stat3 | N/A | 11±3 | 17±3 | - | 0.3±0.1 |
“ | sh-Stat3+Das. | 4±1 | 6±1.1 | 14±3 | - | 0.2±0.1 |
SK-Lu-1 | DMSO | 85±5 | 90±11 | 311±23 | - | 1±0.2 |
“ | CPA7 | 82±4 | 6±1 | 8±3 | - | 0.1 ±0.1 |
CALU-1 | DMSO | 96±9 | 100±10 | 290±12 | - | 0.1 ±0.1 |
“ | CPA7 | 90±12 | 8±2 | 6±1 | - | 0.1 ±0.1 |
SW-900 | DMSO | 100±13 | 100±12 | 405±21 | - | 0.1 ±0.1 |
“ | CPA7 | 96±11 | 12±1 | 11±2 | - | 0.1 ±0.1 |
CALU-6 | DMSO | 95±11 | 93±10 | 300±18 | - | 0.1 ±0.1 |
“ | CPA7 | 93±10 | 10±1 | 15±5 | - | 0.1 ±0.1 |