Figure 2From: Fatal case of sorafenib-associated idiosyncratic hepatotoxicity in the adjuvant treatment of a patient with renal cell carcinoma Histology of post-mortem liver showed a lobular hepatitis with hepatocyte necrosis (a, H&E stain). Histology of the kidneys demonstrated acute tubular necrosis with cellular debris and oxalate crystals within tubules (b, H&E stain) and collecting ducts (c, H&E stain). In addition, collecting ducts contained small numbers of myoglobin casts (d, immunoperoxidase stain).Back to article page