| Investigations | Timing |
---|---|---|
History and Physical Exam including: | · Height (baseline only) | 0,2,4, 6 months |
 | · Weight and Body Mass Index (BMI) |  |
 | · Blood Pressure and Heart Rate |  |
 | · Oxygen saturation (SaO2) (on room air) |  |
 | · Concomitant medications (any changes to baseline meds) |  |
 | · Colinet Co-morbidity Score |  |
 | · Eastern Cooperative Oncology Group Performance Status (ECOG PS) |  |
 | · Disease status |  |
 | · Current treatments |  |
Fitness Testing | · 6-minute walk test (6MWT) | 0,2,4, 6,months |
 | · Senior’s Fitness Test |  |
 | · Hand grip strength |  |
Pulmonary Function | · Forced Expiratory Volume at 1 second (FEV1) | 0,2,4,6 months |
 | · Forced Vital Capacity (FVC) |  |
Adverse Events | · Adverse events will be recorded and graded using National Cancer Institute Common Terminology Criteria for Adverse Events Version 3.0 (NCI CTCAE v3.0) | 0,2,4, 6 months |
Patient Reported Outcomes | · Functional Assessment of Cancer Therapy - Fatigue (FACT-F subscale) | 0,2,4,6 months |
 | · Quality of Life (QOL) European Organisation for Research and Treatment of Cancer –Quality of life questionnaire – Core (EORTC-QLQ-C30) and Lung module (LC-13 subscale) |  |
 | · Depression and Anxiety (General Health Questionnaire - GHQ12) |  |
 | · Sleep Quality (Pittsburgh Sleep Quality Index - PSQI) |  |
 | · Cognitive Function (Functional Assessment of Cancer Therapy – Cognitive scale - FACT-COG v3) |  |
 | · Distress (Distress Thermometer) |  |
 | · Dyspnoea (The University of California, San Diego Shortness of Breath Questionnaire -SOBQ) |  |
 | · Activities of Daily Living (ADLs) and Independent Activities of Daily Living (IADLs) |  |
 | · Sedentary time (Sitting Questionnaire) |  |
 | · Physical activity attitudes (Social Cognitive Determinants of Exercise questionnaire) |  |
Physical Activity Behaviour/ Adherence | · Physical activity participation (Active Australia) | 0,2,4, 6 months |
 | · Accelerometer -for one week prior to each assessment |  |
Other Investigations | · Fasting Serum/plasma collection for correlative studies and optional banking | 0,2,4,6 months |
 | · Glasgow Prognostic score: Full blood count (FBC), Albumin, C-reactive protein (CRP) |  |