Figure 8

Anticancer effect of doxorubicin and/or HSV1-hGM-CSF against 4T1 breast tumors. The mice bearing 4T1 tumors were treated with doxorubicin and/or HSV1-hGM-CSF as described in the Methods section. (A) The tumor volume of mice among the different groups was measured every 4 days following treatments. The data represent the mean ± SEM (n=6). Arrows indicate the type of treatments: thick arrows for doxorubicin chemotherapy and thin arrows for oncolytic HSV1-hGM-CSF treatment. (B) The median survival times for the 4 groups are illustrated in Kaplan–Meier survival curves (n=5-7). ***, p < 0.001. The experiment was performed twice with similar findings. Abbreviations: DOX, doxorubicin; OV, HSV1-hGM-CSF.