Figure 7
Cytotoxic activity to 4T1 ALDH br of CD8 + T lymphocytes from mice following different therapies. (A) The proportion of CD8+ T lymphocytes in spleens after treatments. (B) CD8+ T lymphocyte cytotoxicity to 4T1 ALDHbr by CFSE/PI flow cytometry. Negative control splenocytes were taken from tumor-free naive mice. Statistical analysis was performed using the unpaired Student’s t test: *, p < 0.05; **, p < 0.01; ns, not significant. Abbreviations: DOX, doxorubicin; OV, oncolytic HSV1-hGM-CSF; TLs, T lymphocytes; NC, negative control.