MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1

Table 1 Univariate and multivariate analysis of prognostic factors by Cox regression analysis

Clinicopathological features	Univariate analysis		Multivariate analysis
	RR (95% CI)	P-value	RR (95% CI)	P-value
Male (Male / female)	2.27 (0.87-3.11)	0.108	1.99 (0.67-2.63)	0.112
Age (year) (>60 / ≤60)	1.42 (0.92-1.79)	0.321	2.56 (0.89-3.12)	0.304
Smoking (Smoker / Nonsmoker)	1.65 (0.58-1.88)	0.084	2.13 (0.75-2.70)	0.156
Histological type (SCC / AD)	2.08 (0.39-2.75)	0.202	0.87 (0.46-1.68)	0.286
Clinical stage (III / I + II)	2.76 (1.23-3.82)	0.003	3.13 (0.95-4.03)	0.067
Tumor classification (T₃₊₄ / T₁₊₂)	0.98 (0.44-1.55)	0.215	1.53 (0.74-1.88)	0.082
Lymph node metastasis (N₁₊₂ / N₀)	3.12 (2.03-4.12)	0.016	1.65 (1.12-3.58)	0.036
miR-100 expression (Low / High)	1.74 (1.04-2.36)	0.022	2.44 (1.89-2.95)	0.008

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