Table 1 Genotypic and allelic frequencies of the MDM2 SNP285 and SNP309 in BRCA related ovarian cancer, sporadic ovarian cancer and healthy controls
SNP285 | BRCA1related | BRCA2related | Sporadic disease* | Healthy controls* | |||||
|---|---|---|---|---|---|---|---|---|---|
n | (%) | n | (%) | n | (%) | n | (%) | ||
SNP285 | GG | 153 | (95.0) | 58 | (96.7) | 1260 | (93.7) | 2 274 | (92.3) |
GC | 8 | (5.0) | 2 | (3.3) | 82 | (6.1) | 183 | (7.4) | |
CC | 0 | (0.0) | 0 | (0.0) | 3 | (0.2) | 8 | (0.3) | |
Total | 161 | (100) | 60 | (100) | 1 345 | (100) | 2 465 | (100) | |
G | 314 | (97.5) | 118 | (98.3) | 2 602 | (96.7) | 4 731 | (96.0) | |
C ** | 8 | (2.5) | 2 | (1.7) | 88 | (3.3) | 199 | (4.0) | |
SNP309 | TT | 52 | (32.3) | 22 | (36.7) | 515 | (38.3) | 1 072 | (43.5) |
TG | 81 | (50.3) | 32 | (53.3) | 661 | (49.1) | 1 093 | (44.3) | |
GG | 28 | (17.4) | 6 | (10.0) | 169 | (12.6) | 300 | (12.2) | |
Total | 161 | (100) | 60 | (100) | 1 345 | (100) | 2 465 | (100) | |
T | 185 | (57.5) | 76 | (63.3) | 1 691 | (62.9) | 3 237 | (65.7) | |
G ** | 137 | (42.5) | 44 | (36.7) | 999 | (37.1) | 1 693 | (34.3) | |