Toxicity | Grade 3 | Grade 4 | Grade 5 | Total |
---|---|---|---|---|
Hematologic | Â | Â | Â | 7 (21%) |
 Anemia | 1 (3%) | 0 | 0 | 1 (3%) |
 Neutropenia | 4 (12%) | 1 (3%) | 0 | 5 (15%) |
 Febrile Neutropenia | 0 | 1 (3%) | 0 | 1 (3%) |
 Thrombocytopenia | 0 | 0 | 0 | 0 |
Nonhematologic | Â | Â | Â | Â |
 Cardiac |  |  |  | 4 (12%) |
  Systolic dysfunction | 2 (6%) | 0 | 0 | 2 (6%) |
  Cardiac arrest | 0 | 0 | 1 (3%) | 1 (3%) |
  Myocardial infarction | 0 | 1 (3%) | 1 (3%) | 2 (6%) |
 Edema | 1 (3%) | 0 | 0 | 1 (3%) |
 Fatigue | 10 (29%) | 1 (3%) | 0 | 11 (32%) |
 Infection | 3 (9%) | 0 | 1 (3%) | 4 (12%) |
 Gastrointestinal |  |  |  | 4 (12%) |
  Constipation | 2 (6%) | 0 | 0 | 2 (6%) |
  Diarrhea | 2 (6%) | 0 | 0 | 2 (6%) |
 Pulmonary |  |  |  | 3 (9%) |
  Embolism | 1 (3%) | 0 | 0 | 1 (3%) |
  Pneumonitis | 0 | 0 | 1 (3%) | 1 (3%) |
  Pneumothorax | 0 | 1 (3%) | 0 | 1 (3%) |
 Bladder/Kidney stone | 2 (6%) | 0 | 0 | 2 (6%) |