Table 2 Univariate and multivariable analysis for relapses free period stratified by age for patients naive to systemic treatment

Age

.74

< 40

33

1

0

40-50

98

1.10

0.62-1.96

0

50-60

101

1.29

0.73-2.29

0

> 60

44

1.29

0.66-2.52

154

Grade

.03

0.21

.01

.29

I

31

1

1

24

1

1

II

131

1.45

0.76-2.75

1.06

0.40-2.78

74

1.73

0.66-4.58

1.30

0.48-3.58

III

75

2.17

1.12-4.20

1.54

0.58-4.11

44

3.66

1.39-9.61

2.01

0.70-5.75

Histological type

.54

.53

Ductal

223

1

124

1

Other

15

1.24

0.63-2.45

18

0.74

0.30-1.87

Tumor stage

< .001

0.05

.03

.90

pT1

137

1

1

59

1

1

pT2

109

1.66

1.16-2.37

1.60

1.01-2.55

71

2.23

1.22-4.09

1.16

0.56-2.40

pT3/4

22

2.73

1.57-4.76

2.04

1.07-3.88

18

2.11

0.82-5.45

1.23

0.42-3.63

Nodal stage

< .001

< 0.001

< .001

< .001

Negative

204

1

1

109

1

1

Positive

69

4.25

3.02-5.99

4.44

2.89-6.82

36

3.94

2.28-6.82

3.33

1.77-6.24

ER status

.59

.22

Negative

87

1

40

1

Positive

126

0.90

0.66-1.32

95

1.53

0.78-2.98

PgR status

.78

.78

Negative

84

1

55

1

Positive

123

0.95

0.64-1.40

81

1.08

0.61-1.92

HER2 status

.26

.05

Negative

143

1

105

1

Positive

19

1.44

0.76-2.71

4

0.05

0.00-23.3

ALDH1 status

.01

0.02

.14

Negative

77

1

1

63

1

Positive

116

1.75

1.14-2.68

1.71

1.09-2.68

61

0.64

0.35-1.16