Figure 1

Simvastatin induces cell death and apoptosis in prostate cancer cells. (A) Bar graph showing trypan blue positive PC3 cells treated with control saline, simvastatin, docetaxel or a combination of simvastatin and docetaxel for 12 h. (B) Bar graph showing apoptosis in PC3 cells treated with control saline, simvastatin, docetaxel or a combination of simvastatin and docetaxel for 24 h as measured calorimetrically. (C) Bar graph showing quantification of TUNEL positive PC3 cells treated with control saline, simvastatin, docetaxel or a combination of simvastatin and docetaxel for 24 h. (D) Bar graph showing quantification of TUNEL positive LNCaP cells treated with control saline, simvastatin, docetaxel or a combination of simvastatin and docetaxel for 24 h. (B) Bar graph showing apoptosis in LNCaP cells treated with control saline, simvastatin, docetaxel or a combination of simvastatin and docetaxel for 24 h. The data are presented as mean ± SD (n=4 of quadruplicate experiments).