Additional diagnostic value of tumor markers in cytological fluid for diagnosis of non-small-cell lung cancer

BMC Cancer

Table 4 Comparison of Diagnostic Performance of NAB alone and NAB with Tumor Markers in 194 patients

Tumor marker	AUC	P-value
NAB alone	0.917 (95%CI;0.886-0.948)
NAB with Serum tumor marker
CYFRA (3.3)	0.837 (95%CI;0.778-0.896)	0.009
CEA (5)	0.886 (95%CI;0.838-0.934)	0.408
SCC (2)	0.885 (95%CI;0.838-0.901)	0.207
NAB with Cytological tumor marker
CYFRA (15.7)	0.966 (95%CI;0.940-0.991)	0.009
CEA (0.6)	0.924 (95%CI;0.883-0.965)	0.999
SCC (0.86)	0.811 (95%CI;0.746-0.876)	0.003

Note-Numbers in parentheses are cut-off levels of tumor markers in ng/mL
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; CEA, carcinoembryonic antigen; SCC, squamous cell carcinoma; CYFRA, cytokeratin 19 fragments; NAB, needle aspiration biopsy; AUC, areas under the curve.

ISSN: 1471-2407