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Table 4 Relative intensities of metabolites at pre- and post-treatment

From: Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy

  

Pre-treatment (mean ± SE)

Post-treatment (mean ± SE)

Metabolites

ppm

Survivors

Non-survivors

p-value

Survivors

Non-survivors

p-value

Lactate

4.08-4.13

185.8 ± 11.4

164.6 ± 13.8

0.534

196.2 ± 12.7

250.6 ± 26.0

0.089

Glycine

3.54-3.56

115.0 ± 6.4

120.8 ± 11.0

0.542

91.2 ± 4.1

111.4 ± 8.4

0.033*

GPC

3.22-3.24

167.3 ± 12.4

170.1 ± 23.9

0.949

115.6 ± 6.7

153.9 ± 24.1

0.144

PC

3.21-3.22

247.9 ± 17.0

285.4 ± 34.9

0.338

158.0 ± 16.1

205.5 ± 28.1

0.105

Cho

3.20-3.21

95.4 ± 3.9

108.7 ± 8.3

0.225

79.5 ± 3.7

85.9 ± 6.2

0.276

tCho

3.20-3.24

498.3 ± 26.4

551.3 ± 46.8

0.253

344.9 ± 22.3

434.6 ± 44.6

0.075

Taurine

3.40-3.43

242.6 ± 9.6

222.8 ± 12.4

0.393

248.0 ± 8.1

222.3 ± 9.3

0.144

β-Glucose

4.61-4.64

48.4 ± 3.3

49.3 ± 6.0

1.000

63.6 ± 4.3

53.5 ± 6.6

0.172

  1. The values of relative intensities are integrated peak areas from spectra normalized to equal total areas. Wilcoxon rank sum tests were used for statistical analyses. *p < 0.05, ** p < 0.01