Figure 3

Differences in the bioactivity of human VEGF in bevacizumab-sensitive tumors and bevacizumab-insensitive tumor SC-10-JCK. The bioactivity of VEGF in tumors was determined by the VEGFR2 phosphorylation of HUVEC treated with tumor tissue homogenate administered with bevacizumab or human IgG using western blot (A) and ELISA (B). Each VEGF level in the homogenate was shown in Figure 3A and B.