Table 4 The main ORs of  hOGG1  Ser326Cys polymorphisms in the meta-analysis

326Cys allele versus 326Ser allele (additive model) ^a

All populations

1.06 (0.90, 1.26)

64%

0.01

Random

0.49

Caucasian populations

0.95 (0.85, 1.06)

30%

0.23

Fixed

0.38

Asian populations

1.14 (0.82, 1.57)

75%

0.02

Random

0.44

Hospital-based

1.00 (0.90, 1.11)

51%

0.07

Random

0.99

Studies in HWE

1.01 (0.91, 1.44)

65%

0.02

Random

0.83

Cys/Cys versus Ser/Ser (homozygote contrast) ^a

All populations

1.11 (0.74, 1.66)

65%

0.009

Random

0.63

Caucasian populations

0.87 (0.66, 1.16)

0%

0.41

Fixed

0.35

Asian populations

1.34 (0.64, 2.83)

78%

0.01

Random

0.44

Hospital-based

0.97 (0.65, 1.45)

54%

0.06

Random

0.89

Studies in HWE

1.12 (0.71, 1.79)

71%

0.004

Random

0.62

Cys/Cys versus Cys/Ser + Ser/Ser (recessive genetic model)^a

All populations

1.05 (0.65, 1.70)

79%

<0.0001

Random

0.85

Caucasian populations

0.85 (0.65, 1.21)

25%

0.26

Fixed

0.25

Asian populations

1.26 (0.50, 3.17)

89%

<0.0001

Random

0.62

Hospital-based

0.89 (0.57, 1.38)

66%

0.01

Random

0.59

Studies in HWE

1.14 (0.67, 1.94)

81%

<0.0001

Random

0.64

Cys/Cys + Cys/Ser versus Ser/Ser (dominant genetic model) ^a

All populations

1.07 (0.87, 1.32)

58%

0.03

Random

0.53

Caucasian populations

1.04 (0.74, 1.47)

75%

0.007

Random

0.82

Asian populations

1.16 (0.91, 1.47)

0%

0.85

Fixed

0.23

Hospital-based

1.07 (0.83, 1.36)

64%

0.02

Random

0.61

Studies in HWE

0.97 (0.86, 1.09)

0%

0.45

Fixed

0.59