Table 2 Distribution of genotype and allele frequencies of the hOGG1 Ser326Cys polymorphism
First author [reference] | Genotype | Allele | HWE( p ) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Cases n (%) | Controls n (%) | Cases n (%) | Controls n (%) | ||||||||
Ser/Ser | Ser/Cys | Cys/Cys | Ser/Ser | Ser/Cys | Cys/Cys | Ser | Cys | Ser | Cys | ||
Kim (2005) [19] | 37 (24.2%) | 90 (58.8%) | 26 (17.0%) | 38 (24.8%) | 70 (45.6%) | 45 (29.4%) | 164 (53.6%) | 142 (46.4%) | 146 (47.7%) | 160 (52.3%) | 0.30 |
Karahalil (2006) [23] | 40 (40.4%) | 47 (47.5%) | 12 (12.1%) | 62 (62.0%) | 20 (20.0%) | 18 (18.0%) | 127 (64.1%) | 71 (35.9%) | 144 (72.0%) | 56 (28.0%) | <0.001 |
Huang (2007) [21] | 375 (61.2%) | 209 (34.1%) | 29 (4.73%) | 348 (58.0%) | 216 (36.0%) | 36 (6%) | 959 (78.2%) | 267 (21.8%) | 912 (76.0%) | 288 (24.0%) | 0.75 |
Figueroa (2007) [20] | 649 (59.7%) | 383 (35.2%) | 56 (5.15%) | 596 (58.5%) | 361 (35.5%) | 61 (5.99%) | 1681 (77.3%) | 495 (22.7%) | 1553 (76.3%) | 483 (23.7%) | 0.52 |
Arizono (2008) [17] | 61 (24.3%) | 107 (42.6%) | 83 (33.1%) | 67 (26.7%) | 135 (53.8%) | 49 (19.5%) | 229 (45.6%) | 273 (54.4%) | 269 (53.6%) | 233 (46.4%) | 0.20 |
Narter (2009)[22] | 37 (63.8%) | 13 (22.4%) | 8 (13.8%) | 18 (50.0%) | 18 (50.0%) | 0 (0%) | 87 (75.0%) | 29 (25.0%) | 54 (75.0%) | 18 (25.0%) | 0.08 |
Mittal (2011) [31] | 92 (43.4%) | 93 (43.9%) | 27 (12.7%) | 122 (48.8%) | 111 (44.4%) | 17 (6.8%) | 277 (65.3%) | 147 (34.7%) | 355 (71.0%) | 145 (29.0%) | 0.21 |
Total | 1291 (52.2%) | 942 (38.1%) | 241 (9.74%) | 1251 (52.0%) | 931 (38.7%) | 226 (9.39%) | 3524 (71.2%) | 1424 (28.8%) | 3433 (71.3%) | 1383 (28.7%) | 0.006 |