Bax expression measured by AQUAnalysis is an independent prognostic marker in oral squamous cell carcinoma

BMC Cancer

Table 1 Association of demographic and clinico-pathological characteristics with expression levels of Bax, Bcl-2 and Bcl-XL

	N=69		Univariate Analysis			Bax^a		n=64	Bcl-2^a		n=63	Bcl-XL^a		n=63
	# OF CASES	(%)	Hazard Ratio	95% CI	p-value	Low	High	p-value	Low	High	p-value	Low	High	p-value
GENDER			1.72	0.693 - 4.286	0.24			0.419			0.109			0.419
Male	49	71.01				20	24		18	25		20	23
Female	20	28.99				12	8		13	7		12	8
AGE ^b			1.35	0.543 - 3.364	0.52			1.000			0.315			0.616
<60 years	29	42.03				15	14		12	17		16	13
≥60 years	40	57.97				17	18		19	15		16	18
pT STATUS			2.55	1.022 - 6.357	0.05			0.616			0.207			0.616
1 + 2	38	55.07				19	16		20	15		19	16
3 + 4	31	44.93				13	16		11	17		13	15
pN STATUS			7.470	2.467 - 22.611	<0.0001			0.315			0.802			1.000
N0	39	56.52				15	20		16	18		17	17
N1 + N2	30	43.48				17	12		15	14		15	14
SMOKING HISTORY			0.65	0.245 - 1.702	0.38			0.075			0.148			0.237
Never	15	21.74				11	4		10	5		10	5
Ever	54	78.26				21	28		21	27		22	26
ALCOHOL HISTORY			0.46	0.162 - 1.282	0.14			1.000			1.000			1.000
Never	11	17.46				5		4	4	5		5	4
Ever	52	82.54				27	23		23	26		24	24
TUMOUR DIFFERENTIATION			1.62	0.772 - 3.427	0.2			1.000			0.923			0.525
Well	14	22.95				7	6		6	7		8	5
Moderate	38	62.30				18	18		19	16		15	20
Poor	9	14.75				4	3		4	3		3	4
TREATMENT			2.16	0.629 - 7.412	0.22			0.257			0.011			0.164
Surgery	18	26.09				6	11		13	4		6	11
Surgery + RXT	51	73.91				26	21		18	28		26	20
STAGE			4.68	1.358 - 16.087	0.01			1.000			0.797			1.000
I + II	26	37.68				11	12		12	11		12	11
III + IV	43	62.32				21	20		19	21		20	20
PROLIFERATION (Ki67)			0.6	0.231 - 1.539	0.29			0.001			0.617			0.211
Low	32	50.00				23	9		17	15		19	13
High	32	50.00				9	23		14	17		13	18

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