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Table 1 Characteristics of case–control studies of hepatitis viruses infection and ICC risk

From: Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis

First author

Year

Country

Cases

(n)

Control

(n)

Control description

OR (95% CI)

for HBV infection

OR (95% CI)

for HCV infection

Study quality

Parkin

1991

Thailand

100

100

Hospital-based control

1.0 (0.4-2.1)

–

1

Shin

1996

Korea

41

406

Hospital-based control

1.3 (0.3-5.3)

3.9 (0.9-17.1)

2

Donato

2001

Italy

26

824

Hospital-based control

2.7 (0.4-18.5)

9.7 (1.6-58.9)

2

Yamamoto

2004

Japan

50

205

Hospital-based control

1.8 (0.3-10.1)

16.8 (5.7-50.0)

2

Shaib

2005

US

625

90834

Population-based control

0.8 (0.1-5.9)

6.1 (4.3-8.6)

2

Choi

2006

Korea

185

185

Hospital-based control

0.8 (0.198-3.023)

1.0(0.04-25.264)

2

Shaib

2007

US

83

236

Hospital-based control

2.9 (0.1-236.8)

7.9 (1.3-84.5)

2

Welzel

2007

US

535

102782

Population based control

–

4.4 (1.4-14.0)

1

Lee

2008

Korea

622

2488

Hospital-based control

2.3 (1.6-3.3)

1.0 (0.5-1.9)

2

Zhou

2008

China

312

438

Hospital-based control

8.876 (5.98-13.19)

0.933 (0.281-3.1)

2

Lee

2009

Taiwan

160

160

Hospital-based control

4.985 (2.78-8.95)

2.71 (1.16-6.32)

2

Tao

2010

China

61

380

Hospital-based control

18.1 (7.5-44.0)

–

1

Peng

2011

China

98

196

Hospital-based control

2.75 (1.27-5.95)

–

1

  1. ICC, intrahepatic cholangiocarcinoma; HBV,hepatitis B virus; HCV, hepatitis C virus; US, United States.