Table 1 Characteristics of studies included in the analysis
Reference | Country | Study Design | Subjects (number) | Menopausal Condition PreM/PostM | Index Tests (Methods) | Cut-off Value | Proven cancer N (%) |
|---|---|---|---|---|---|---|---|
Abdel-Azeez et al., 2010 | Egypt | Cross-section | 65 | 18/47 | HE4 (EIA); CA125 (ECLIA) | HE4: 72pM; CA125: 35U/mL | OC: 41 (63.1%) |
Bandiera et al., 2011 | Italy | Cross-section | 419 | 134/284 (1 patient with unknown stage was not analyzed) | ROMA | ROMA: preM 7.4% postM 25.3%; | EOC: 114 (27.2%) |
| Â | Â | Â | Â | Â | HE4 (CMIA); | HE4: preM 70pM, postM 140pM; | Â |
| Â | Â | Â | Â | Â | CA125 (CMIA) | CA125: 35U/mL | Â |
Chang et al., 2011 | China | Cross-section | 118 | - | HE4 (EIA); CA125 (EIA) | HE4: 150pM; CA125: 35U/mL | OC: 52 (44.1%) |
Holcomb et al., 2011 | USA | Cross-section | 229 | 229/- | HE4 (CMIA); CA125 (CMIA) | HE4: 70pM; CA125: 35U/mL | EOC: 18 (7.86%) |
Jacob et al., 2011 | Switzerland | Cross-section | 160 | 84/76 | ROMA | ROMA: 13.1% | EOC: 29 (18.1%) |
| Â | Â | Â | Â | Â | HE4 (ELISA); CA125 (ELISA) | HE4: 70pM; CA125: 35U/mL | OC: 56 (35%) |
Kim et al., 2011 | Korea | Cross-section | 159 | 51/108 | ROMA | ROMA: preM 7.6% postM 10.9%; | EOC: 72 (45.3%) |
|  |  |  |  |  | HE4 (CMIA); CA125 (CMIA) | HE4: 70pM; CA125: 35 IU/mL | OC: 78 (49.1%) |
Montagnana et al., 2011 | Italy | Cross-section | 104 | 51/53 | ROMA | ROMA: preM12.5% postM14.4%; | EOC: 55 (52.9%) |
| Â | Â | Â | Â | Â | HE4 (EIA); CA125 (CLEIA) | HE4: 74.2pM; CA125: 35U/mL | Â |
Moore et al., 2008 | USA | Cross-section | 233 | - | HE4 (EIA); CA125 (RIA) | - | EOC: 67 (28.8%) |
Moore et al., 2009 | USA | Cross-section | 531 | 248/283 | ROMA | ROMA: preM 13.1% postM 27.7% | EOC: 129 (26.8%) |
| Â | Â | Â | Â | Â | HE4 (EIA); CA125 (CMIA) | Â | OC: 154 (29.0%) |
Moore et al., 2011 | USA | Cross-section | 472 | 255/217 | ROMA | ROMA: preM 13.1%; postM 27.7% | EOC: 48 (10.2%) |
| Â | Â | Â | Â | Â | HE4 (ELISA); CA125 (CMIA) | Â | Â |
Van Gorp et al., 2011 | Belgium | Cross-section | 389 | 184/205 | ROMA | ROMA: preM 12.5% postM 14.4%; | OC: 161 (41.4%) |
| Â | Â | Â | Â | Â | HE4 (EIA); CA125 (EIA) | HE4: 70pM;CA125: 35U/mL | Â |