Relapse Free Period | Â | UNIVARIATE | MULTIVARIATE | ||||
---|---|---|---|---|---|---|---|
 | N | HR | 95% CI | p-value | HR | 95% CI | p-value |
Age | Â | Â | Â | Â | Â | Â | Â |
< 40 | 48 | 1.00 | Â | 0.422 | Â | Â | Â |
40-50 | 145 | 0.97 | 0.612-1.539 | Â | Â | Â | Â |
50-60 | 132 | 1.17 | 0.734-1.853 | Â | Â | Â | Â |
> 60 | 249 | 0.90 | 0.574-1.408 | Â | Â | Â | Â |
Grade | Â | Â | Â | Â | Â | Â | Â |
I | 80 | 1.00 | Â | 0.001 | 1.00 | Â | 0.473 |
II | 282 | 1.43 | 0.945-2.172 | Â | 1.18 | 0.711-1.948 | Â |
III | 203 | 2.02 | 1.326-3.078 | Â | 1.34 | 0.802-2.231 | Â |
Histological type | Â | Â | Â | Â | Â | Â | Â |
Ductal | 513 | 1.00 | Â | 0.291 | Â | Â | Â |
Other | 53 | 1.24 | 0.832-1.846 | Â | Â | Â | Â |
Tumor stage | Â | Â | Â | Â | Â | Â | Â |
pT1 | 211 | 1.00 | Â | < 0.001 | 1.00 | Â | 0.298 |
pT2 | 272 | 1.59 | 1.205-2.093 | Â | 1.17 | 0.832-1.637 | Â |
pT3/4 | 72 | 2.49 | 1.706-3.635 | Â | 1.45 | 0.908-2.316 | Â |
Nodalstage | Â | Â | Â | Â | Â | Â | Â |
pN- | 307 | 1.00 | Â | < 0.001 | 1.00 | Â | < 0.001 |
pN+ | 250 | 3.06 | 2.379-3.945 | Â | 2.70 | 1.987-3.669 | Â |
ER-status | Â | Â | Â | Â | Â | Â | Â |
Negative | 203 | 1.00 | Â | 0.725 | Â | Â | Â |
Positive | 337 | 1.05 | 0.808-1.359 | Â | Â | Â | Â |
PgR-status | Â | Â | Â | Â | Â | Â | Â |
Negative | 223 | 1.00 | Â | 0.744 | Â | Â | Â |
Positive | 313 | 0.96 | 0.743-1.236 | Â | Â | Â | Â |
HER2 | Â | Â | Â | Â | Â | Â | Â |
No overexpression | 378 | 1.00 | Â | 0.401 | Â | Â | Â |
Overexpression | 44 | 1.21 | 0.776-1.883 | Â | Â | Â | Â |
Endocrine therapy | Â | Â | Â | Â | Â | Â | Â |
ET- | 481 | 1.00 | Â | 0.197 | Â | Â | Â |
ET+ | 93 | 1.24 | 0.896-1.705 | Â | Â | Â | Â |
Chemotherapy | Â | Â | Â | Â | Â | Â | Â |
CT- | 444 | 1.00 | Â | 0.839 | Â | Â | Â |
CT+ | 130 | 0.97 | 0.730-1.291 | Â | Â | Â | Â |
MIC-AB & ULBP-2 | Â | Â | Â | Â | Â | Â | Â |
Both Low | 68 | 1.00 | Â | < 0.001 | 1.00 | Â | < 0.001 |
Either one high | 275 | 0.59 | 0.426-0.820 | Â | 0.54 | 0.380-0.757 | Â |
Both high | 64 | 0.38 | 0.230-0.612 | Â | 0.41 | 0.246-0.682 | Â |