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Table 1 Summary of the included studies

From: Detection of cervical lymph node metastasis in head and neck cancer patients with clinically N0 neck—a meta-analysis comparing different imaging modalities

Author

year

Journal

Modality

TP

FP

FN

TN

Sensitivity (95%CI)

Specificity (95% CI)

QUADAS

Stevens MH

1985

Arch Otolaryngol Head Neck Surg

CT

5

1

1

9

83%(54-100%)

90%(71-100%)

9

Maremonti P

1997

J Craniomaxillofac Surg

CT

6

0

6

12

50%(22-78%)

100%

7

Righi PD

1997

Head Neck

CT

6

0

4

23

60%(30-90%)

100%

7

Byers RM

1998

Head Neck

CT

2

2

9

12

18%(0-41%)

86%(67-100%)

5

Myers LL

1998

Laryngoscope

CT

4

1

3

9

57%(21-94%)

90%(71-100%)

10

Takes RP

1998

Int J Radiat Oncol Biol Phys

CT

14

3

12

35

54%(35-73%)

92%(84-100%)

11

Akoglu E

2005

J Otolaryngol

CT

2

1

1

10

67%(13-100%)

91%(74-100%)

10

Wilson GR

1994

Br J Plast Surg

MRI

11

14

0

13

100%

48%(29-67%)

11

Braams JW

1995

J Nucl Med

MRI

3

2

2

5

60%(17-100%)

71%(38-100%)

7

Maremonti P

1997

J Craniomaxillofac Surg

MRI

4

4

8

8

33%(7-60%)

67%(40-93%)

7

Yucel T

1997

Acta Radiol

MRI

4

1

1

12

80%(45%-100%)

92%(78-100%)

10

Akoglu E

2005

J Otolaryngol

MRI

2

1

1

10

67%(13-100%)

91%(74-100%)

10

Thomsen JB

2005

Acta Radiol

MRI

5

4

9

52

36%(11-61%)

93%(86-100%)

7

Braams JW

1995

J Nucl Med

PET

5

2

0

5

100%

71%(38-100%)

7

Myers LL

1998

J Otolaryngol

PET

7

0

0

4

100%

100%

10

Myers LL

1998

Laryngoscope

PET

7

0

2

15

78%(51-100%)

100%

10

Kau RJ

2002

Arch Otolaryngol Head Neck Surg

PET

1

1

4

6

20%(0-55%)

86%(60-100%)

13

Brouwer J

2004

Eur Arch Otorhinolaryngol

PET

2

1

1

11

67%(13-100%)

92%(76-100%)

9

Akoglu E

2005

J Otolaryngol

PET

2

1

1

10

67%(13-100%)

91%(74-100%)

10

Schoder H

2006

J Nucl Med

PET

6

4

3

23

67%(36-98%)

85%(72-99%)

10

Wensing BM

2006

Laryngoscope

PET

3

4

5

16

38%(4-71%)

80%(63-98%)

11

Iyer NG

2010

Head Neck

PET

15

4

14

113

52%(34-70%)

97%(93%-100%)

12

Liao CT

2010

J Nucl Med

PET

26

66

33

143

55%(31-57%)

68%(62-75%)

13

Richard C

2010

Arch Otolaryngol Head Neck Surg

PET

7

5

1

8

88%(65-100%)

62%(35-88%)

11

van den Brekel MW

1993

Eur Arch Otorhinolaryngol

US

21

13

15

39

58%(42-74%)

75%(63-87%)

9

Maremonti P

1997

J Craniomaxillofac Surg

US

8

1

4

11

67%(40-93%)

92%(76-100%)

7

Righi PD

1997

Head Neck

US

6

5

4

18

60%(30-90%)

78%(61-95%)

7

Byers RM

1998

Head Neck

US

3

4

8

10

27%(1-54%)

71%(48-95%)

5

Takes RP

1998

Int J Radiat Oncol Biol Phys

US

18

11

8

27

69%(52-87%)

71%(57-86%)

11

Hodder SC

2000

Br J Oral Maxillofac Surg

US

9

4

3

17

75%(51-100%)

81%(64-98%)

7

Akoglu E

2005

J Otolaryngol

US

3

4

0

7

100%

64%(35-92%)

10

Thomsen JB

2005

Acta Radiol

US

13

10

2

55

87%(70-100%)

85%(76-93%)

7

  1. TP: true positive; FP: false positive; FN: false negative; FP: false positive.
  2. QUADAS: Quality Assessment of Diagnostic Accuracy Studies.
  3. Sensitivities and specificities with 95% confidence interval (CI) values were reported for individual studies.