Table 2 Chromosome imbalance regions with different alteration frequency in relation to tumor subtypes in lung cancer
Chromosome | Cytoband | Start site | End site | Size (Mb) | BAC number | ADCa (n=20) | SCCa (n=20) | Difference in alteration frequency |
|---|---|---|---|---|---|---|---|---|
A. Asian | ||||||||
2 | p24.1 | 20863719 | 22199349 | 1.30 | 10 | Loss :85% | Loss :30% | 55% |
3 | p25.2-25.3 | 9867502 | 12488641 | 2.60 | 18 | Loss :25% | Gain :40% | 65% |
6 | p22.1 | 28165236 | 28452189 | 0.30 | 6 | Gain :85% | Gain :25% | 60% |
10 | q22.3 | 77428562 | 79105320 | 1.70 | 17 | Gain :15% | Loss :45% | 60% |
10 | q24.1 | 98845671 | 99207113 | 0.36 | 4 | Gain :50% | Gain :70% | 20% |
17 | p13.1 | 7918593 | 7993947 | 0.10 | 2 | Loss :10% | Gain :45% | 55% |
17 | q24.2 | 62769444 | 63340772 | 0.60 | 5 | Loss :60% | 0 | 60% |
B. Caucasian | ||||||||
2 | p23.3 | 23804032 | 26257119 | 2.45 | 17 | Gain :60% | 0 | 60% |
3 | p11.2-12.1 | 85893658 | 87649703 | 1.76 | 14 | Loss :100% | Loss :40% | 60% |
3 | p14.2-14.3 | 56804094 | 61897044 | 5.09 | 33 | Gain :20% | Gain :80% | 60% |
3 | p22.2-24.1 | 29648645 | 38540543 | 8.89 | 25 | Loss :70% | 0 | 70% |
4 | p15.2-15.3 | 21407638 | 23952439 | 2.54 | 27 | 0 | Loss :80% | 80% |
6 | p12.3 | 47804985 | 47961964 | 0.16 | 2 | 0 | Gain :60% | 60% |
6 | p22.1-22.2 | 25985490 | 26318093 | 0.33 | 5 | 0 | Gain :50% | 50% |
6 | q21.1 | 73325343 | 73596310 | 0.27 | 2 | Loss :60% | 0 | 60% |
9 | q22.2-22.3 | 76902029 | 78697046 | 1.80 | 17 | Loss :50% | Gain :20% | 70% |
10 | q21.2 | 74105644 | 74697200 | 0.59 | 6 | 0 | Gain :60% | 60% |
12 | p13.3 | 8010296 | 9309215 | 1.30 | 11 | Loss :90% | Loss :10% | 80% |
12 | q24.2 | 63460935 | 64329625 | 0.87 | 14 | Loss :10% | Loss :60% | 50% |
17 | p22.2 | 15476489 | 15931167 | 0.45 | 4 | Gain :60% | 0 | 60% |
X | q21.3 | 87836131 | 89896378 | 2.06 | 17 | 0 | Gain :60% | 60% |